Umblical Artery Systolic \Diastolic Ratio and Amniotic Fluid Index in Prediction of Fetal Outcome in Term Pregnancy

NCT06347913 | Not Yet Recruiting

• 1 other identifier: Soh-Med-24-03-09MS
• Study Type: observational
• Target: 213
• Locations: 1 country
• Sites: 1

Brief Summary

Antepartum fetal surveillance is the cornerstone of management in pregnancy. \[1\] It is done primarily to reduce the incidence of adverse fetal outcomes. It minimizes morbidity by optimizing the timing of delivery. Fetus at risk of chronic hypoxia is identified and unnecessary interventions are avoided. However, fetal surveillance acts as a diagnostic modality to detect the influence of maternal, placental, and fetal factors on the fetus. The timely detection of morbid changes in the fetal status followed by adequate interventions to avoid death or disability is one of the most important objectives of prenatal care. \[2\] Tests now commonly done for antepartum fetal surveillance are nonstress test (NST), amniotic fluid index (AFI), biophysical profile, Doppler study of umbilical artery (UA), and middle cerebral artery (MCA).\[3 6\] However, AFI and UA Doppler velocimetry both form an essential part of the antenatal surveillance in the assessment of fetal well being. UA Doppler is a powerful tool that allows the obstetrician to follow a sequence of fetal hemodynamic events that happen in response to placental insufficiency. \[7\] However, several studies have reported higher sensitivities and specificities for UA Doppler ratio for prediction of fetal prognosis. \[3 6\] Amniotic fluid is the product of complex and dynamic fetal and placental physiologic processes. Disruption of the fine balance may result in overproduction or underproduction of fluid. Liquor adequacy often reflects the fetal status. Oligohydramnios is associated with increased perinatal loss. Furthermore, other studies indicate that UA velocimetry is a predictor of adverse outcomes in pregnancies complicated by oligohydramnios. \[8,9\] Thus, arterial Doppler velocimetry measurement may be useful in predicting adverse pregnancy outcomes adjunct to other antenatal surveillance tests, especially the AFI. Therefore, the present study will be done to evaluate the comparative assessment of UA ratio and AFI in predicting adverse perinatal outcomes.

Conditions

Umblical Artery Doppler in Term Pregnancy

Outcome Measures

Primary Outcomes (1)

• Umbilical Artery Systolic/Diastolic Ratio

  Umblical Artery Systolic/Diastolic Ratio

  6 months

Interventions

ultrasound RADIATION

Umbilical Artery Systolic/Diastolic Ratio and Amniotic Fluid Index in Prediction of Fetal Outcome in Term Pregnancies

Also known as: umblical artery doppler in term pregnancy

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

pregnant women term

You may qualify if:

• \* Age of mother 18-40 years
• Term pregnancy (37w6d -40w)
• Singleton pregnancy

You may not qualify if:

• \*Multiple pregnancy
• Preterm pregnancy before 37w
• Preeclampsia
• IUGR
• Diabetic
• Congenital anomalies of fetus

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Egypt

Location

Related Publications (1)

• Arduini D, Rizzo G, Romanini C. Changes of pulsatility index from fetal vessels preceding the onset of late decelerations in growth-retarded fetuses. Obstet Gynecol. 1992 Apr;79(4):605-10.

  PMID: 1553186 BACKGROUND

MeSH Terms

Interventions

High-Energy Shock Waves

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Central Study Contacts

sabrin A alnokrashy, resident

CONTACT

01093395389; drsabrin444@gmail.com

Salah r roshdy, professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident at obstetric and gynacology department at sohag university hospial

Study Record Dates

• First Submitted: March 11, 2024
• First Posted: April 4, 2024
• Study Start: April 1, 2024
• Primary Completion: August 1, 2024
• Study Completion: March 1, 2025
• Last Updated: April 4, 2024

Record last verified: 2024-04

Locations

EG (1)