Attentional Capture by Real-life Episodic Information

NCT06934902 | Not Yet Recruiting

• 1 other identifier: 69HCL25_0108
• Study Type: interventional
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral (VAN) cortex. However, typical laboratory experiments emphasize task-specific processing, neglecting the possible role of memory. Although a few studies have examined the contribution of memory to attention control, they have generally used simple tasks in the laboratory. These tasks are unlikely to produce true traces of episodic memory, which are - by definition - characterized by complex contextual information (what, where, when) and personal relevance. This research will therefore use an innovative protocol based on mobile phone technology to generate episodes in the participants' real lives and then measure the impact of these past personal experiences on attention allocation (by assessing eye movements) and on the activity of the DAN/VAN system (using functional imaging). The main hypothesis of the study is that knowledge acquired during everyday life contributes to the subsequent allocation of processing resources, via engagement of the DAN/VAN attention systems.

Conditions

Healthy Volunteers; Attentional Capture

Keywords

Healthy volunteers; Attentional capture; real-life episodic information

Outcome Measures

Primary Outcomes (1)

• activation pattern in fMRI: "old vs. new" objects (intervention 1)

  activation pattern in DAN/VAN system in fMRI experiments for the comparison of trials with gaze directed towards "seen/old vs. unseen/new" objects.

  One time during the week after the 3 weeks encoding phase

Secondary Outcomes (2)

• activation pattern in fMRI: "place" images in intervention 1

  One time during the week after the 3 weeks encoding phase

• activation pattern in fMRI: incongruent vs. congruent contexts (intervention 2)

  One time during the week after the 3 weeks encoding phase

Study Arms (2)

Old vs new objects

EXPERIMENTAL

The following week after the "Old vs new objects" encoding phase of 3 weeks, participants will have an fMRI. During fMRI, participants will see objects already seen or not seen during the encoding phase.

Behavioral: Old vs new objects" encoding phase and fMRI

incongruent vs. congruent contexts

EXPERIMENTAL

The following week after the "incongruent vs. congruent contexts" encoding phase of 3 weeks, participants will have an fMRI. During fMRI, participants will see objects encoding in congruent or incongruent contexts.

Behavioral: " incongruent vs. congruent contexts " encoding phase and fMRI

Interventions

Old vs new objects" encoding phase and fMRI BEHAVIORAL

During the encoding phase, a set of 60 objects will be presented to the participants in their everyday life. Pictures of objects sent to their app mobile phone over a period of 3 weeks. The following week, participants will have an fMRI. During fMRI, participants will see objects already seen or not seen during the encoding phase.

Old vs new objects

" incongruent vs. congruent contexts " encoding phase and fMRI BEHAVIORAL

During the encoding phase, a set of 60 objects will be presented to the participants in their everyday life. Pictures of objects sent to their app mobile phone over a period of 3 weeks. This time, the objects will be chosen according to the participant's location. The following week, participants will have an fMRI. During fMRI, participants will see objects encoding in congruent/incongruent contexts.

incongruent vs. congruent contexts

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be 18 years old to 40 years old
• Be right-handed
• Do not wear glasses
• Have a mobile-phone compatible with the application, minimum 6rd generation Android operating system, with geo-localization activated and accepted by the user
• Undertake to comply with the instructions and recommendations for MRI examination
• Provide informed written consent to participate in the study

You may not qualify if:

• History of known neurological or psychiatric illness
• Cognitive problems limiting the understanding of instructions
• Recent taking psychotropic drugs (antidepressants, anxiolytics, antipsychotics). The main treatments not authorized during this research are the following: Psychotropic treatments (drugs that can induce changes in perception, sensation, mood, consciousness or behavior). Like what:
• Antipsychotics (valproic acid, amisulpride, aripiprazole, clozapine, cyamemazin, haloperidol, loxapine, olanzapine, risperidone).
• Antidepressants (Amitriptyline, Citalopram, Clomipramine, Duloxetine, Escitalopam, Fluoxetine, Mianserine, Mirtazapine, Nortriptyline, Paroxetine, Sertraline, Venlafaxine).
• Anxyolitics
• Pregnant or breastfeeding women
• Persons deprived of their liberty by a judicial or administrative decision
• Persons admitted to a health or social institution for purposes other than research
• Adults subject to a legal protection measure (guardianship, curatorship)
• Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
• Participation in another research study of the current study
• Contraindication for fMRI scanning
• Participant not agreeing to be informed in the event of the incidental discovery of an anomaly on MRI
• For visit number 2 :

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

UCBL1, CRNL Inserm U1028, CNRS UMR5292, équipe IMPACT

Bron, Rhone, 69500, France

Location

Central Study Contacts

Emiliano MACALUSO, Pr

CONTACT

04 72 91 34 07; emiliano.macaluso@univ-lyon1.fr

Samy Adrian FOUDIL

CONTACT

07 77 36 37 68; samy@samalgo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Our main hypothesis concerning the role of personal past experiences in guiding spatial attention via the dorsal and ventral attention control system (DAN/VAN) will be tested in two fMRI studies in healthy participants. The use of mobile-mobile technology will allow us to control the formation of episodic memory traces in the real-world. In the testing phase, eye-tracking will permit us to assess the allocation of spatial attention, and fMRI will assess the activation of the attention systems as a function of condition (gaze/attention towards elements associated with previous personal experiences, i.e. pictures of old/seen objects or places, vs. pictures of new/unseen objects/places).

Study Record Dates

• First Submitted: April 11, 2025
• First Posted: April 18, 2025
• Study Start: December 15, 2025
• Primary Completion (Estimated): January 15, 2029
• Study Completion (Estimated): January 15, 2029
• Last Updated: April 18, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)