NCT06932991

Brief Summary

This retrospective, single-blind, parallel group study investigates the efficacy of Cognitive Stimulation Therapy (CST) compared to Reality Orientation and Reminiscence Therapy (RO\&RM) in enhancing cognitive and functional domains in older adults with mild to moderate dementia.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
160

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Sep 2021

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2021

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 2, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 2, 2025

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

April 10, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 17, 2025

Completed
Last Updated

May 31, 2025

Status Verified

April 1, 2025

Enrollment Period

3.6 years

First QC Date

April 10, 2025

Last Update Submit

May 30, 2025

Conditions

Keywords

older adultsdementia

Outcome Measures

Primary Outcomes (1)

  • Kendrick Cognitive Test for the Elderly (KCTE).

    Participants' attention and episodic memory were quantified using the Kendrick Cognitive Test for the Elderly (KCTE).

    Baseline line and six-month

Secondary Outcomes (1)

  • The Chinese Disability Assessment for Dementia (CDAD)

    Baseline and 6-month after the start of the program

Study Arms (2)

Cognitive Stimulation Therapy

Therapy in the CST arm focused on improving participants' attention span, memory and problem-solving skills using paper and pen, table games or computer programs.

Behavioral: Cognitive Remediation

RO&RM arm

with the use of orientation boards, calendars, clocks, verbal reminders, and different environmental cues to reduce participants' confusion, disorientation and behavioral problems.

Behavioral: Cognitive Remediation

Interventions

cognitive remediation

Cognitive Stimulation TherapyRO&RM arm

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Older people who are residence in a 24/7 care home

You may qualify if:

  • participants had to be 65 years old or above, live in Hong Kong and had a diagnosis for dementia in medical history

You may not qualify if:

  • any major neurological illness other than dementia, any psychiatric disorder or a known history of substance abuse.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Northumbria University

UK, United Kingdom

Location

Related Publications (2)

  • Spector A, Thorgrimsen L, Woods B, Royan L, Davies S, Butterworth M, Orrell M. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br J Psychiatry. 2003 Sep;183:248-54. doi: 10.1192/bjp.183.3.248.

    PMID: 12948999BACKGROUND
  • Mok CC, Siu AM, Chan WC, Yeung KM, Pan PC, Li SW. Functional disabilities profile of chinese elderly people with Alzheimer's disease - a validation study on the chinese version of the disability assessment for dementia. Dement Geriatr Cogn Disord. 2005;20(2-3):112-9. doi: 10.1159/000086612. Epub 2005 Jun 30.

    PMID: 15990425BACKGROUND

MeSH Terms

Conditions

Dementia

Interventions

Cognitive Remediation

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Behavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

April 10, 2025

First Posted

April 17, 2025

Study Start

September 1, 2021

Primary Completion

April 2, 2025

Study Completion

April 2, 2025

Last Updated

May 31, 2025

Record last verified: 2025-04

Data Sharing

IPD Sharing
Will not share

Locations