NCT04373668

Brief Summary

Dementia is a devastating condition characterised by progressive loss of cognition leading to loss of independence and eventually death. One major unmet need, which remains a critical challenge for care provision, is the management of night-time care and sleep-related symptoms in people with dementia living in care homes. The causes and impacts of sleep disturbances in people with dementia in care homes are complex and multi-faceted, indicating the need of a whole-systems approach to the issue. It will require a tailored, person-centred approach which accounts for the environmental, personal and clinical factors contributing to the symptoms. The aim of this study is to evaluate the NightCAP intervention to improve treatment of sleep disturbance in people with dementia in care homes, with the goal of reducing sleep disturbance behaviour and reducing the use of hypnotic drugs. This will provide robust evidence to support guidance on night time care and improving hypnotic drug prescribing, both of which are major unmet needs in the care of people with dementia.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
720

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2021

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 28, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 4, 2020

Completed
1.5 years until next milestone

Study Start

First participant enrolled

November 1, 2021

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2023

Completed
Last Updated

July 27, 2022

Status Verified

July 1, 2022

Enrollment Period

1.5 years

First QC Date

April 28, 2020

Last Update Submit

July 25, 2022

Conditions

Keywords

DementiaCare HomesHypnotic MedicationNight Time CareBehavioural symptomsCost effectiveness

Outcome Measures

Primary Outcomes (1)

  • Sleep Disturbance Inventory SDI

    Sleep disturbance behaviour as measured by the Sleep Disturbance Inventory SDI

    From baseline and immediately after intervention

Secondary Outcomes (11)

  • Change of Hypnotic Drug Use

    From baseline, immediately after intervention and at four months follow-up

  • Dementia Quality of Life

    From baseline, immediately after intervention and at four months follow-up

  • Neuropsychiatric Inventory- Nursing Home (NPI-NH)

    From baseline, immediately after intervention and at four months follow-up

  • Cohen-Mansfield Agitation Inventory (CMAI)

    From baseline, immediately after intervention and at four months follow-up

  • Global Deterioration Scale (GDS)

    From baseline, immediately after intervention and at four months follow-up

  • +6 more secondary outcomes

Study Arms (2)

Control, optimised usual care

NO INTERVENTION

Treatment delivered as usual in the care home

Hypnotic Drug Review, Structured Sleep Hygiene and NightCAP

EXPERIMENTAL

Care homes to receive all three interventions: Hypnotic Drug Review, Structured Sleep Hygiene and NightCAP interventions

Behavioral: Hypnotic Medication ReviewBehavioral: Structured Sleep HygieneBehavioral: Night Time Care Activities Programme

Interventions

A training programme focused providing guidance on the review and withdrawal process of hypnotic drugs.

Hypnotic Drug Review, Structured Sleep Hygiene and NightCAP

Training module on the principle of good sleep hygiene

Hypnotic Drug Review, Structured Sleep Hygiene and NightCAP

Training and support package to assist in the development of a personalised night time care plan and support the implementation and dissemination of information within the care home environment

Hypnotic Drug Review, Structured Sleep Hygiene and NightCAP

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Care homes (inclusive of residential and nursing) that have failed to meet more than 1 of the 5 CQC care home quality standards check
  • Care homes who have at least 12 eligible care home resident participants
  • Care homes with a minimum of two residents who are eligible to participate in the study taking hypnotic medication
  • Resident participants will have an established or probable diagnosis of dementia
  • Residents will have experienced an episode/occurrence of sleep disturbance behaviour in the past four weeks/two weeks (as reported by care staff)
  • Care home member of staff whose duties include providing care to individuals with dementia
  • Care home care staff are required to have an adequate level of English language to complete all required assessment outcomes
  • Care home care staff participants who will remain in work without plans for extended leave over the study period

You may not qualify if:

  • Care homes receiving special support from the local authority
  • Agency care staff
  • Care staff will be able to withdraw from the study at any time

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Exeter

Exeter, Devon, EX1 2LU, United Kingdom

RECRUITING

MeSH Terms

Conditions

DementiaBehavioral Symptoms

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental DisordersBehavior

Study Officials

  • Anne Corbett

    University of Exeter

    STUDY CHAIR

Central Study Contacts

Kayleigh Nunez

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 28, 2020

First Posted

May 4, 2020

Study Start

November 1, 2021

Primary Completion

April 30, 2023

Study Completion

April 30, 2023

Last Updated

July 27, 2022

Record last verified: 2022-07

Data Sharing

IPD Sharing
Will not share

Locations