NCT06922916

Brief Summary

This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results. It gathers patient data from hospital and Mediston systems, with main focus on in-hospital complications and secondary focus on ICU stay, post-op hospitalization, mortality, and intubation time. The research aims to deepen understanding of anesthetic management's role in lung transplant outcomes and guide improvements in perioperative anesthesia protocols.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
250

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 3, 2025

Completed
8 days until next milestone

First Posted

Study publicly available on registry

April 11, 2025

Completed
11 days until next milestone

Study Start

First participant enrolled

April 22, 2025

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 6, 2026

Completed
24 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2026

Completed
Last Updated

April 22, 2025

Status Verified

April 1, 2025

Enrollment Period

12 months

First QC Date

April 3, 2025

Last Update Submit

April 21, 2025

Conditions

COPDInterstitial PneumoniaBronchiectasisRespiratory FailureIdiopathic Pulmonary Fibrosis (IPF)SilicosisPulmonary TuberculosisPulmonary HypertensionPulmonary Heart Disease

Keywords

lung transplantatipnPerioperative-related risksMortalityIn-hospital complicationsPrognosis

Outcome Measures

Primary Outcomes (1)

  • In-hospital adverse events

    In-hospital adverse events were defined as post-transplant complications occurring prior to discharge, such as: Grade 3 PGD, respiratory infections, stroke, cardiac events, AKI, or liver impairment.

    Collect data for an expected average about 2 hours

Secondary Outcomes (6)

  • ICU stay

    Collect data for an expected average about 2 hours

  • Postoperative hospital stay

    Collect data for an expected average about 2 hours

  • In-hospital mortality

    Collect data for an expected average about 2 hours

  • 30-day postoperative mortality

    Collect data for an expected average about 2 hours

  • 90-day postoperative mortality

    Collect data for an expected average about 2 hours

  • +1 more secondary outcomes

Other Outcomes (6)

  • Grade 3 Primary Graft Dysfunction (PGD)

    Collect data for an expected average about 2 hours

  • Pulmonary Infection

    Collect data for an expected average about 2 hours

  • Acute Kidney Injury

    Collect data for an expected average about 2 hours

  • +3 more other outcomes

Study Arms (1)

Lung transplantation group

In this group, we collected perioperative clinical data and analyzed risk factors associated with patient outcomes.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University between January 2017 and October 2024

You may qualify if:

  • Age \>18 years at time of transplantation
  • Received single or bilateral lung transplantation

You may not qualify if:

  • Re-transplantation
  • Multi-organ transplantation
  • Autotransplantation
  • Incomplete medical records: Recipients with \>20% missing essential data elements in any of these categories:Preoperative baseline characteristics； Intraoperative parameters；Postoperative outcome measures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000

Hangzhou, Zhejiang, 310000, China

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic ObstructiveLung Diseases, InterstitialBronchiectasisRespiratory InsufficiencyIdiopathic Pulmonary FibrosisSilicosisTuberculosis, PulmonaryHypertension, PulmonaryPulmonary Heart Disease

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsBronchial DiseasesRespiration DisordersPulmonary FibrosisPneumoconiosisLung InjuryOccupational DiseasesTuberculosisMycobacterium InfectionsActinomycetales InfectionsGram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfectionsRespiratory Tract InfectionsHypertensionVascular DiseasesCardiovascular DiseasesHeart Diseases

Central Study Contacts

Diansan Su, Dr

CONTACT

+8618616514088diansansu@yahoo.com

chaoqin Chen, Dr

CONTACT

+8613567148312chenchaoqin09@126.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chair of the Department of Anesthesiology

Study Record Dates

First Submitted

April 3, 2025

First Posted

April 11, 2025

Study Start

April 22, 2025

Primary Completion

April 6, 2026

Study Completion

April 30, 2026

Last Updated

April 22, 2025

Record last verified: 2025-04

Locations

CN(1)