Mechanistic Studies of Chronic COPD Using Single-Cell Sequencing and Single-Cell Spatial Transcriptomics

NCT07208123 | Not Yet Recruiting

• 1 other identifier: HSCRNACOPD-001
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD.

Conditions

COPD

Outcome Measures

Primary Outcomes (1)

• Transcriptomic profile analysis of lung tissues

  until end of surgery

Study Arms (1)

COPD group

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

150

You may qualify if:

• Receiving lung resection surgery at the hospital for any reason；
• Diagnosed with COPD according to the 2024 GOLD guidelines；
• Tissue samples that meet collection requirements and are either agreed to be collected or already preserved；

You may not qualify if:

• Improper preservation of pathological specimens, refusal to consent to sample collection, or incomplete clinical information；
• Combined with other factors causing obstructive airflow limitation;
• Diagnosed with asthma according to the GINA 2023 guidelines and with a history of asthma exacerbations within the past year;
• Combined with Advanced lung cancer;
• Receiving systemic immunosuppressive medications such as anti-rejection drugs;

Sponsors & Collaborators

• Tongji University: lead

Study Sites (1)

Renji Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200444, China

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Feng Xinyu, Dr

CONTACT

86-17621694653; 52290946015@stu.ecnu.edu.cn

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: September 27, 2025
• First Posted: October 6, 2025
• Study Start: September 30, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027
• Last Updated: October 6, 2025

Record last verified: 2025-09

Locations

CN (1)