Promoting Adherence to Chemotherapy Handling Guidelines Among Oncology Nurses

NCT06919653 | Not Yet Recruiting

• 2 other identifiers: 2024-0038K01OH012671
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Chemotherapy exposure is a serious occupational hazard affecting oncology nurses. Oncology nurses' adherence to chemotherapy handling guidelines is essential to prevent their exposure to chemotherapy. The goal of this research is to develop, validate, and pilot test an intervention "Workplace program to Improve Safe Handling of hazardous drugs" (WISH), to promote adherence to chemotherapy handling guidelines among oncology nurses. The WISH intervention includes two components: an educational component and debriefing sessions on chemotherapy exposure incidents. First, the research team will use a mixed-methods approach to develop an online educational component on chemotherapy safety, establish the content validity of the educational content based on experts' evaluation, and establish the face validity of the educational content by conducting three qualitative focus group with oncology nurses (n=4-6 nurses per group) or individual interviews. Next, the research team will test the feasibility and acceptability of the intervention using a pilot randomized controlled trial with two groups of oncology nurses, an intervention group (n= 30) and a control group (n=30). We will obtain quantitative and qualitative measures of the intervention feasibility and acceptability. The output is an intervention program targeted to train nurses on safe chemotherapy handling guidelines. Findings will be disseminated through peer-reviewed publications and presentations. The intermediate outcome is the adoption of the intervention program by healthcare institutions to train nurses on chemotherapy handling guidelines. The end outcome is promoting adherence to chemotherapy handling guidelines among oncology nurses.

Conditions

Handling Guidelines; Oncology Nurse; Adherence; Chemotherapy Exposure

Outcome Measures

Primary Outcomes (1)

• Nurses' adherence to chemotherapy handling guidelines

  This variable will be measured using Hazardous Drug Handling Questionnaire. The scores reflect the percentage of time nurses adhere to chemotherapy handling guidelines and range between 0%-100%. A higher score indicates greater adherence to chemotherapy handling guidelines.

  Baseline, 6 weeks after the intervention, and 12 weeks after the intervention

Secondary Outcomes (2)

• Nurses' health beliefs regarding chemotherapy exposure

  Baseline, 6 weeks after the intervention, and 12 weeks after the intervention

• Knowledge on chemotherapy safety

  Baseline, 6 weeks after the intervention, and 12 weeks after the intervention

Other Outcomes (2)

• Study feasibility

  Baseline, 6 weeks after the intervention, and 12 weeks after the intervention

• Intervention acceptability

  6 weeks after the intervention, and 12 weeks after the intervention

Study Arms (2)

WISH Intervention Group

EXPERIMENTAL

Participants will receive the WISH intervention (education on chemotherapy exposure risks and safe handling guidelines and debriefing sessions on chemotherapy exposure incidents) in addition to the traditional education on chemotherapy safety typically offered by their institution.

Behavioral: The Workplace program to Improve the Safe Handling of hazardous drugs (WISH)

Control Group

NO INTERVENTION

Participants will not receive intervention in this study. They will receive the traditional education on chemotherapy safety typically offered by their institution.

Interventions

The Workplace program to Improve the Safe Handling of hazardous drugs (WISH) BEHAVIORAL

The WISH intervention is targeted to promote the adherence to chemotherapy handling guidelines among oncology nurses. The WISH intervention will include two components 1) an individualized online educational component on chemotherapy exposure and the safe handling guidelines with incorporating novel instructional technology tools and 2) debriefing sessions on the incidents of chemotherapy exposure.

WISH Intervention Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• being at least 18 years old
• able to read and speak English
• working as an oncology nurse for at least 3 months
• handling chemotherapy drugs at work

You may not qualify if:

• None

Sponsors & Collaborators

• University of Cincinnati: lead
• National Institute for Occupational Safety and Health (NIOSH/CDC): collaborator

Study Sites (1)

University of Cincinnati

Cincinnati, Ohio, 45221, United States

Location

Central Study Contacts

Dania Abu-Alhaija, PhD

CONTACT

513-558-5147; abualhdm@ucmail.uc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be randomized into intervention and control groups. Nurses in the intervention group will receive the WISH intervention (online individualized education and debriefing sessions) and the traditional education typically offered by their institution. Nurses in the control group will receive the traditional education typically offered through their institution.

Study Record Dates

• First Submitted: April 2, 2025
• First Posted: April 9, 2025
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 1, 2027
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

US (1)