Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages
1 other identifier
interventional
3,000
1 country
1
Brief Summary
The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is: Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group? Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence. Participants are required to complete two questionnaires: one before and one after they receive their RESET results.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2025
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 25, 2025
CompletedFirst Submitted
Initial submission to the registry
February 11, 2026
CompletedFirst Posted
Study publicly available on registry
February 17, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 1, 2028
April 13, 2026
April 1, 2026
2.1 years
February 11, 2026
April 7, 2026
Conditions
Outcome Measures
Primary Outcomes (3)
Intention to adopt a healthier diet
A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.
From enrollment to 3 months after results have been returned.
Intention to engage in Physical Activity
A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.
From enrollment to 3 months after results have been returned.
Intention to visit a General Practitioner
A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.
3 months after results have been returned.
Other Outcomes (1)
Big Five Inventory - 44
From enrollment
Study Arms (3)
Personality-Tailored Message
EXPERIMENTALGeneral Message
ACTIVE COMPARATORControl
NO INTERVENTIONInterventions
The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.
The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.
Eligibility Criteria
You may qualify if:
- New participants of RESET who have given consent to be contacted for future studies
- ≥21 years old
You may not qualify if:
- are not able to read, write or communicate in English
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National University of Singapore
Singapore, 117599, Singapore
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
February 11, 2026
First Posted
February 17, 2026
Study Start
November 25, 2025
Primary Completion (Estimated)
January 1, 2028
Study Completion (Estimated)
November 1, 2028
Last Updated
April 13, 2026
Record last verified: 2026-04