Cardiac Magnetic Resonance in Non Ischemic Cardiomyopathy

NCT03638271 | Unknown

• 1 other identifier: Non ischemic cardiomyopathy MR
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cardiac magnetic resonance imaging has been established as a promising three dimensional imaging modality with the ability to assess cardiac morphology, ventricular function, perfusion, viability and imaging characteristics of the surrounding vasculature without ionizing radiation. The accurate treatment of patients with cardiac disorders has created the need for accurate and reproducible measurements of cardiac chamber volumes and function. Cardiac magnetic resonance has the ability to provide this information as well as assess edema, perfusion, viability and vascular anatomy.

Conditions

Cardiac Magnetic Resonance Imaging in Non Ischemic Cardiomyopathy

Outcome Measures

Primary Outcomes (4)

• Cardiac morphological measurements.

  Detection of cardiac wall thickness and ventricular systolic/diastolic diameters. all these measures in millimeters using cardiac magnetic resonance and compare results with echocardiography.

  Within two year

• Cardiac contractility of each part

  Visual assessment of cardiac motility in term of normo- , hypo-, or dys-kinesia using cardiac magnetic resonance and compare results with echocardiography.

  Within two year

• Measurements of severity and prognosis of nonischemic cardiomyopathic patients

  Detection of cardiac muscle replacement and fibrosis by delayed myocardial enhancement using cardiac magnetic resonance, which is indicator of severity and prognosis of disease.

  Within two year

• Assessment of cardiac function.

  Calculation of ejection fraction in percentage.

  Within two years

Secondary Outcomes (1)

• Diagnosis and differentiation of different types of non-ischemic cardiomyopathic types.

  Within two years

Study Arms (1)

nonischemic cardiomyopathic patient

OTHER

Patients in different sex and age groups diagnosed with any type of nonischemic cardiomyopathy clinically or with echocardiography will undergo cardiac magnetic resonance imaging.

Diagnostic Test: Cardiac magnetic resonance imaging

Interventions

Cardiac magnetic resonance imaging DIAGNOSTIC_TEST

Patients in different sex and age groups diagnosed with any type of nonischemic cardiomyopathy clinically or with echocardiography will undergo cardiac magnetic resonance imaging and compare their results.

nonischemic cardiomyopathic patient

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients in different sex and age groups with any type of cardiomyopathy and others non cardiomyopathic cases

You may not qualify if:

• Non compatible implantable devices with magnetic resonance machine in some cases as presence of anti para-magnetic substance as pacemakers.
• In severely ill patients as severe renal impairment (risk of nephrogenic systemic fibrosis)
• Those with sever claustrophobia.
• Dysrhythmia affecting ECG-gating.
• Early pregnancy.

Sponsors & Collaborators

• Reham Sameeh: lead
• Assiut University: collaborator

Related Publications (15)

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  PMID: 17916581 BACKGROUND

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  PMID: 15998698 BACKGROUND

• O'Donnell DH, Abbara S, Chaithiraphan V, Yared K, Killeen RP, Martos R, Keane D, Cury RC, Dodd JD. Cardiac MR imaging of nonischemic cardiomyopathies: imaging protocols and spectra of appearances. Radiology. 2012 Feb;262(2):403-22. doi: 10.1148/radiol.11100284.

  PMID: 22282181 BACKGROUND

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  PMID: 10442682 BACKGROUND

• WRITING COMMITTEE MEMBERS; Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL; American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013 Oct 15;128(16):e240-327. doi: 10.1161/CIR.0b013e31829e8776. Epub 2013 Jun 5. No abstract available.

  PMID: 23741058 BACKGROUND

• Williams TJ, Manghat NE, McKay-Ferguson A, Ring NJ, Morgan-Hughes GJ, Roobottom CA. Cardiomyopathy: appearances on ECG-gated 64-detector row computed tomography. Clin Radiol. 2008 Apr;63(4):464-74. doi: 10.1016/j.crad.2007.07.024. Epub 2007 Nov 5.

  PMID: 18325368 BACKGROUND

• Pohost GM. The history of cardiovascular magnetic resonance. JACC Cardiovasc Imaging. 2008 Sep;1(5):672-8. doi: 10.1016/j.jcmg.2008.07.009. No abstract available.

  PMID: 19356498 BACKGROUND

• Marwick TH, Schwaiger M. The future of cardiovascular imaging in the diagnosis and management of heart failure, part 1: tasks and tools. Circ Cardiovasc Imaging. 2008 Jul;1(1):58-69. doi: 10.1161/CIRCIMAGING.108.792408. No abstract available.

  PMID: 19808515 BACKGROUND

• Boxt LM. Cardiac MR imaging: a guide for the beginner. Radiographics. 1999 Jul-Aug;19(4):1009-25; discussion 1026-8. doi: 10.1148/radiographics.19.4.g99jl161009.

  PMID: 10464806 BACKGROUND

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• American College of Cardiology Foundation Task Force on Expert Consensus Documents; Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, Ho VB, Jerosch-Herold M, Kramer CM, Manning WJ, Patel M, Pohost GM, Stillman AE, White RD, Woodard PK. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010 Jun 8;55(23):2614-62. doi: 10.1016/j.jacc.2009.11.011. No abstract available.

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• Rajiah P, Raza S, Saboo SS, Ghoshhajra B, Abbara S. Update on the Role of Cardiac Magnetic Resonance in Acquired Nonischemic Cardiomyopathies. J Thorac Imaging. 2016 Nov;31(6):348-366. doi: 10.1097/RTI.0000000000000226.

  PMID: 27438188 BACKGROUND

Study Officials

• Reham Sameeh, assistant lecturer

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

. Samya Abd El.Aziz, Prof

CONTACT

01006788053; samy5abdelaziz@yahoo.com

Moustafa Hashem, Prof.

CONTACT

01000684012; hashemradiol@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assisstant lecturer

Model Details: prospective manner study will include 50 patients of both sex and different age with any type of cardiomyopathy diagnosed clinically or by Doppler echocardiography, will undergo cardiac magnetic resonance.

Study Record Dates

• First Submitted: June 20, 2018
• First Posted: August 20, 2018
• Study Start: October 1, 2021
• Primary Completion: October 1, 2021
• Study Completion: October 1, 2021
• Last Updated: September 29, 2021

Record last verified: 2020-10