Patterns of Arrhythmias and Conduction Block in COVID-19 Patients and Its Relation to Myocardial Injury Detected by Cardiac Magnetic Resonance

NCT04584411 | Unknown

• 1 other identifier: arrhythmias in COVID-19
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Detection of the incidence and types of arrhythmia and conduction block in COVID - 19 patients Detection and description of CMR patterns of myocardial injury in COVID-19 patients with arrhythmias.

Conditions

Covid19

Outcome Measures

Primary Outcomes (1)

• Evaluation of the incidence of arrhythmia and conduction block in COVID-19 patients using Holter

  baseline

Secondary Outcomes (1)

• Detection of myocardial injury in COVID-19 patients using CMR.

  baseline

Interventions

Cardiac Magnetic resonance imaging DIAGNOSTIC_TEST

The following basic sequences will be conducted: * Cine imaging using SSFP sequence for cardiac structure and function. * Tissue characterization imaging, T1 and T2. * Myocardial perfusion imaging. * Late gadolinium enhancement. Diagnosis of myocarditis will be based on the modified Lake Louise criteria: T2-weighted: any of the following standard T2 sequences: regional high signal standard T2 sequences: global signal intensity ratio (myocardium/skeletal muscle) ≥2 T2 mapping: increased T2 relaxation times T1-weighted: any of the following late enhancement imaging: non-ischemic (subepicardial or mid myocardial) late enhancement native T1 mapping: increased T1 relaxation times or extracellular volume supportive criteria: signs of pericarditis: effusion or pericardial late enhancement regional or global wall motion abnormalities\[5\]

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will include 50 confirmed COVID-19 patients admitted to Assiut University Heart Centre and critical care unit, internal medicine department within the next 6 months complaining of arrhythmias and heart block. These patients will be followed-up for a period of 6 months after discharge.

You may qualify if:

• COVID 19 suspected patients presented by chest pain, dyspnea, chest discomfort \&/or palpitations
• ECG changes (LBBB, PVCs, ventricular tachycardia, AF, atrial flutter, ST-T changes, and conduction defects).
• Increased inflammatory markers and / or Tropnin-I.

You may not qualify if:

• COVID 19 patients without ECG changes.
• Patients known to have the same pattern of arrhythmia or conduction system defects before Covid-19 infection.
• Patients contraindicated for CMR.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Pirzada A, Mokhtar AT, Moeller AD. COVID-19 and Myocarditis: What Do We Know So Far? CJC Open. 2020 May 28;2(4):278-285. doi: 10.1016/j.cjco.2020.05.005. eCollection 2020 Jul.

  PMID: 32691024 BACKGROUND

• Bhatla A, Mayer MM, Adusumalli S, Hyman MC, Oh E, Tierney A, Moss J, Chahal AA, Anesi G, Denduluri S, Domenico CM, Arkles J, Abella BS, Bullinga JR, Callans DJ, Dixit S, Epstein AE, Frankel DS, Garcia FC, Kumareswaram R, Nazarian S, Riley MP, Santangeli P, Schaller RD, Supple GE, Lin D, Marchlinski F, Deo R. COVID-19 and cardiac arrhythmias. Heart Rhythm. 2020 Sep;17(9):1439-1444. doi: 10.1016/j.hrthm.2020.06.016. Epub 2020 Jun 22.

  PMID: 32585191 BACKGROUND

• Shirazi S, Mami S, Mohtadi N, Ghaysouri A, Tavan H, Nazari A, Kokhazadeh T, Mollazadeh R. Sudden cardiac death in COVID-19 patients, a report of three cases. Future Cardiol. 2021 Jan;17(1):113-118. doi: 10.2217/fca-2020-0082. Epub 2020 Jul 3.

  PMID: 32615807 BACKGROUND

• B. Siripanthong et al., "Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- company ' s public news and information website . Elsevier hereby grants permission to make all its COVID-19-r," no. January, 2020.

  BACKGROUND

• Ferreira VM, Schulz-Menger J, Holmvang G, Kramer CM, Carbone I, Sechtem U, Kindermann I, Gutberlet M, Cooper LT, Liu P, Friedrich MG. Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations. J Am Coll Cardiol. 2018 Dec 18;72(24):3158-3176. doi: 10.1016/j.jacc.2018.09.072.

  PMID: 30545455 BACKGROUND

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Doaa A Fouad, Doctorate

  Assiut University

  PRINCIPAL INVESTIGATOR

• Alaa A El-Moniem, Doctorate

  Assiut University

  PRINCIPAL INVESTIGATOR

• Mohamed A.H Abdelhafez, Doctorate

  Assiut University

  PRINCIPAL INVESTIGATOR

• Shimaa S Khider, Doctorate

  Assiut University

  PRINCIPAL INVESTIGATOR

• Ahmed AR Hassaan, bachelor

  Assiut University

  PRINCIPAL INVESTIGATOR

• Maram M Shafiq, student

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed AR Hassaan, bachelor

CONTACT

+201068115040; ahmed.hassaan1994@yahoo.com

Doaa A Fouad, Doctorate

CONTACT

+201001085828; fouaddoaa@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: September 9, 2020
• First Posted: October 14, 2020
• Study Start: November 1, 2020
• Primary Completion: November 1, 2021
• Study Completion: January 1, 2024
• Last Updated: October 14, 2020

Record last verified: 2020-10