NCT06915103

Brief Summary

This case illustrates the clinical, radiologic, and histopathologic features of Anti-NMDAR encephalitis and underscores the importance of MRI in detecting ovarian teratomas when pelvic ultrasound is inconclusive.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2024

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 20, 2024

Completed
18 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 8, 2024

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 19, 2024

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

April 1, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 8, 2025

Completed
Last Updated

April 8, 2025

Status Verified

April 1, 2025

Enrollment Period

18 days

First QC Date

April 1, 2025

Last Update Submit

April 1, 2025

Conditions

Anti-NMDA Receptor EncephalitisMature TeratomaParaneoplastic Syndromes

Keywords

Magnetic ResonanceGynecologic Surgery

Outcome Measures

Primary Outcomes (1)

  • Anti-NMDA Encephalitis

    Diagnosis of Anti-NMDA Encephalitis based on pelvic MRI

    1 week

Interventions

Magnetic Resonance Imaging (MRI)DIAGNOSTIC_TEST

A pelvic MRI with and without contrast was performed for evaluation of the ovary.

Salpingo-oophorectomyPROCEDURE

Salpingo-oophorectomy procedure was performed on the left ovary.

Eligibility Criteria

Age34 Years - 34 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Female patient presenting to emergency department with acute psychosis, characterized by alternating episodes of catatonia and mania, regressive speech, and inappropriate behaviors.

You may qualify if:

  • Suspected Anti-NMDA Encephalitis

You may not qualify if:

  • Inability to consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States

Location

MeSH Terms

Conditions

Anti-N-Methyl-D-Aspartate Receptor EncephalitisDermoid CystParaneoplastic Syndromes

Interventions

Magnetic Resonance ImagingSalpingo-oophorectomy

Condition Hierarchy (Ancestors)

Paraneoplastic Syndromes, Nervous SystemNervous System NeoplasmsNeoplasms by SiteNeoplasmsEncephalitisBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurodegenerative DiseasesNeuroinflammatory DiseasesAutoimmune Diseases of the Nervous SystemAutoimmune DiseasesImmune System DiseasesCystsTeratomaNeoplasms, Germ Cell and EmbryonalNeoplasms by Histologic Type

Intervention Hierarchy (Ancestors)

TomographyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisOvariectomyCastrationEndocrine Surgical ProceduresSurgical Procedures, OperativeUrogenital Surgical ProceduresGynecologic Surgical ProceduresSalpingectomy

Study Officials

  • Tri A. Dinh, MD

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

April 1, 2025

First Posted

April 8, 2025

Study Start

June 20, 2024

Primary Completion

July 8, 2024

Study Completion

December 19, 2024

Last Updated

April 8, 2025

Record last verified: 2025-04

Data Sharing

IPD Sharing
Will not share

Locations

US(1)