CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
CAMERA
1 other identifier
interventional
80
1 country
1
Brief Summary
The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy
Started Jan 2026
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 28, 2023
CompletedFirst Posted
Study publicly available on registry
January 23, 2024
CompletedStudy Start
First participant enrolled
January 22, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2029
March 5, 2026
March 1, 2026
2.9 years
December 28, 2023
March 3, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Pulmonary Capillary Wedge Pressure (PCWP) at rest
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter at rest.
Baseline
Pulmonary Capillary Wedge Pressure (PCWP) during exercise
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.
Baseline
Secondary Outcomes (20)
Trans-cardiac uptake of free fatty acids (FFA) at rest
Baseline
Trans-cardiac uptake of free fatty acids (FFA) during exercise
Baseline
Trans-cardiac uptake of glucose at rest
Baseline
Trans-cardiac uptake of glucose during exercise
Baseline
Trans-cardiac uptake of ketone bodies at rest
Baseline
- +15 more secondary outcomes
Study Arms (1)
Healthy Volunteers
EXPERIMENTALHealthy volunteers with no history of Heart Failure (HF) will undergo a Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, MRI, and DEXA scan.
Interventions
Right Heart Catheterization (RHC) with Hemodynamics and Limited Echocardiogram is an invasive procedure that involves insertion of a catheter through a blood vessel in the neck, groin, or arm to the right side of the heart. Hemodynamic measurements such as the blood pressure inside the veins, heart, and arteries as well as measurements of blood flow and how much oxygen is in the blood will be completed during the catheterization procedure. It is a way to see how well the heart is working during your procedure. During the RHC procedure a limited echocardiogram, using ultrasound waves, will be collected to evaluate the structure and function of the heart. All measurements will be conducted at rest and during exercise using a supine cycle ergometer
MRI is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body. CMR Imaging will assess myocardial structure, function, and fat content. An additional limited MRI sequence of the the abdomen and one sequence in the thigh will be used to evaluate for visceral adipose tissue (VAT) as a measurement of body composition.
A DEXA scan measures the amount of fat in the body using an x-ray that measures bone, calcium and fat.
Eligibility Criteria
You may qualify if:
- Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
- Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
- Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
- Informed consent were obtained.
- No history of heart failure.
- Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.
You may not qualify if:
- Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
- Any diagnosis of heart failure
- Symptomatic coronary artery disease (e.g., patients with chronic angina)
- Symptomatic valvular heart disease
- Pulmonary hypertension
- Cardiomyopathies
- High output heart failure
- Pericardial disease
- Clinically significant chronic lung disease in the opinion of the investigators
- Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men)
- Estimated glomerular filtration rate ≤30mL/min
- Pregnant women
- Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Barry Borlaug, MD
Mayo Clinic
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
December 28, 2023
First Posted
January 23, 2024
Study Start
January 22, 2026
Primary Completion (Estimated)
January 1, 2029
Study Completion (Estimated)
January 1, 2029
Last Updated
March 5, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will not share