Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Following Days

NCT06908408 | Completed

• 2 other identifiers: UMCLj-BE-PlateletIrena Grad
• Study Type: observational
• Target: 484
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies have revealed that a relative platelet count decline in patients after their admission to the intensive care unit (ICU) is a very reliable marker of the severity of their sickness. ICU patients with a greater platelet count decline after their admission to the ICU have generally worse outcome. Investigators assume that a quick appearance of a deep metabolic acidosis, which commonly occurs in critically ill, has an important role in pathogenesis of relative platelet count decline. To evaluate this, correlation of metabolic acidosis severity in participants upon admission to the ICU with platelet count decline in 2 days, following admission, was investigated with a retrospective observational study, analysing all participants, admitted to the ICU in one year period (in 2020). As a measurement of metabolic acidosis severity, investigators took base excess (BE) value (expressed in mmol/L) from arterial blood gas analysis with lowest pH in participants in around admission time (in a period from 24 hours before to 24 hours after their admission to the ICU). To calculate relative platelet count decline in 2 days after admission to the ICU, investigators took platelet count on admission to the ICU (P0) and lowest platelet count on day 2 after the patient's admission (P2). Following formula was used to calculate relative platelet count decline in 2 days after ICU admission (delta P): delta P = (P2-P0)/P0 x 100 (expressed in %). More negative values of delta P represent larger relative platelet count decline. The main interest of the study was if BE value correlates with delta P. Investigators assumed that participants with a more severe metabolic acidosis upon admission to the ICU (represented with more negative BE value) would tend to have a larger relative platelet count decline in 2 days, following admission to the ICU (represented with more negative value of delta P). Pearson correlation was used to evaluate correlation between BE and delta P.

Conditions

Platelet Count Decline in Critically Ill; Metabolic Acidosis; Metabolic Acidosis Severity; Platelet Count Decline in ICU Patients

Keywords

metabolic acidosis severity; BE; relative platelet count decline in critically ill; base excess; platelet count decline in critically ill

Outcome Measures

Primary Outcomes (1)

• Relative platelet count decline in participants from admission to the ICU to their second day after ICU admission

  In this observational study relative platelet count decline in participants from admission to the ICU to their second day after the admission to the ICU was measured (with the aim to analyse correlation between metabolic acidosis severity in participants upon admission to the ICU and platelet count trend in participants in the following 2 days). Platelet count value in participants upon admission to the ICU (P0) and lowest platelet count value on day 2 after the admission to the ICU (P2) were used to calculate relative platelet count decline in 2 days after ICU admission (delta P), using formula: delta P = (P2-P0)/P0 x 100 (delta P expressed in %).

  From admission to the ICU (base line) and 2 days following admission

Interventions

Corrrelation between metabolic acidosis severity in patients on admission to the ICU and platelet count trend in 2 days following admission was investigated DIAGNOSTIC_TEST

The aim of the study was to investigate if there exists any correlation between metabolic acidosis severity in patients upon admission to the ICU and platelet count trend in 2 days, following admission.

Eligibility Criteria

• Age: 14 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study has been conducted at the Department of Anaesthesiology and Surgical Intensive Care at University Medical Centre Ljubljana. All participants, admitted to the ICU of Department of Anaesthesiology and Surgical Intensive Care in 2020 were included.

You may qualify if:

• Admitted to the ICU department in a 1 year period (from 1st January to 31th December 2020)

You may not qualify if:

• Lacking blood gas analysis data on admission
• Incomplete platelet count data (lacking platelet count on admission to the ICU and day 2 after the admission)

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Study Sites (1)

University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia

Ljubljana, Slovenia, 1000, Slovenia

Location

Related Publications (14)

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MeSH Terms

Conditions

Acidosis

Condition Hierarchy (Ancestors)

Acid-Base Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Primož Gradišek, MD, PhD, Prof.

  Department of Anaesthesiology and Surgical Intensive Care

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 22, 2025
• First Posted: April 3, 2025
• Study Start: January 11, 2024
• Primary Completion: February 11, 2024
• Study Completion: February 14, 2024
• Last Updated: April 3, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR, ANALYTIC CODE
• Time Frame: Beginning with publication of results with no end date.
• Access Criteria: After publication of results all IPD data of the study can be shared on request on email of investigator: irena.grad@gmail.com

Locations

SL (1)