Sugammadex Reduces Antiemetic Effect of Dexamethasone

NCT06901596 | Not Yet Recruiting

• 1 other identifier: 2204574
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Sugammadex is a medication used for reversal of muscle relaxation during procedures under general anesthesia. It works by encapsulating muscle relaxant molecules with a steroid ring in its structure. On the other hand, postoporative nause and vomiting (PONV) is an adverse outcome during anesthesia. PONV can be prevented with pharmacologic agents such as ondansetron and dexamethasone. Dexamethasone is a steroidal agent that can interact with sugammadex. In theory, this interaction could lead to reduced effectiveness of sugammadex. In fact, several studies have explored this interaction. However, the effect of sugammadex on the antiemetic effect of dexamethasone has not been evaluated. This study intends to evaluate this interaction.

Conditions

PONV

Keywords

sugammadex; dexamethasone; PONV; perioperative; surgery

Outcome Measures

Primary Outcomes (1)

• Rate of PONV

  Number of events of PONV during 2 hours after admission to PACU

  2 hours after admission to PACU

Study Arms (2)

Dexamethasone

Surgical patients who received dexamethasone as prophylactic antiemetic

Dexamethasone + sugammadex

Patients who received dexamethasone intraoperatively and sugammadex to reverse muscle relaxation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult surgical patients scheduled for elective surgery

You may qualify if:

• Older than 18 years old
• Elective surgery
• ASA 1, 2, 3
• At least one risk factor for PONV

You may not qualify if:

• Pregnancy
• Receiving antiemetics prior to arrival to preoperative holding area
• Receiving opioids prior to arrival to preoperative holding area
• Admission to ICU
• Altered mental status
• Rapid sequence induction
• Nausea or vomiting before surgery

Sponsors & Collaborators

• Augusta University: lead

Related Publications (5)

• Park HY, Choi HR, Kim YB, Oh SK, Kim T, Yang HS, In J. Chronic exposure to dexamethasone may not affect sugammadex reversal of rocuronium-induced neuromuscular blockade: an in vivo study on rats. Anesth Pain Med (Seoul). 2023 Jul;18(3):275-283. doi: 10.17085/apm.23021. Epub 2023 Jul 14.

  PMID: 37468197 BACKGROUND

• Choi H, Park SY, Kim YB, In J, Yang HS, Lee JS, Kim S, Park S. Effects of dexamethasone and hydrocortisone on rocuroniuminduced neuromuscular blockade and reversal by sugammadex in phrenic nerve-hemidiaphragm rat model. Korean J Anesthesiol. 2019 Aug;72(4):366-374. doi: 10.4097/kja.d.18.00238. Epub 2019 Mar 19.

  PMID: 30886132 BACKGROUND

• Koo CH, Hwang JY, Min SW, Ryu JH. A Meta-Analysis on the Effect of Dexamethasone on the Sugammadex Reversal of Rocuronium-Induced Neuromuscular Block. J Clin Med. 2020 Apr 24;9(4):1240. doi: 10.3390/jcm9041240.

  PMID: 32344687 BACKGROUND

• Lim BG, Won YJ, Kim H. The effect of dexamethasone on sugammadex reversal of rocuronium-induced neuromuscular blockade in surgical patients undergoing general anesthesia: A systematic review and meta-analysis. Medicine (Baltimore). 2021 Feb 5;100(5):e23992. doi: 10.1097/MD.0000000000023992.

  PMID: 33592855 BACKGROUND

• Batistaki C, Pandazi A, Kyttari A, Kaminiotis E, Kostopanagiotou G. Is there an interaction between dexamethasone and sugammadex in real clinical conditions? A randomized controlled trial in patients undergoing laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol. 2019 Apr-Jun;35(2):215-219. doi: 10.4103/joacp.JOACP_42_17.

  PMID: 31303711 BACKGROUND

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Central Study Contacts

Efrain Riveros Perez, MD

CONTACT

7067217361; eriverosperez@augusta.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Anesthesiology

Study Record Dates

• First Submitted: March 19, 2025
• First Posted: March 30, 2025
• Study Start: April 1, 2025
• Primary Completion: June 30, 2025
• Study Completion: July 15, 2025
• Last Updated: March 30, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share