Aromatherapy Treatment With Lavender Essential Oil to Reduce Post-Operative Nausea and Vomiting (PONV)

NCT07176676 | Active Not Recruiting DMC

• 1 other identifier: AziendaABCA
• Study Type: interventional
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effectiveness of aromatherapy through the use of inhaled Lavender oil in reducing patients' nausea during the post-operative period.

Conditions

PONV

Keywords

nausea; vomit; lavanda; Postoperative

Outcome Measures

Primary Outcomes (1)

• To evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period

  To reduce nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period. Endpoint Reduction of nausea by at least 10% compared to treatment with standard care, as assessed by the NRS (Numerical Rating Scale).

  during the 24-hour post-operative period

Secondary Outcomes (2)

• To evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period

  during the 24-hour postoperative period

• o evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period

  during the 24-hour postoperative period

Study Arms (2)

Lavender Yes

EXPERIMENTAL

The lavender essential oil may only be used at the first episode of nausea occurring within 24 hours post-surgery; during the same period, if nausea occurs again, it will be treated as per standard care

Other: Lavanda Angustifolia essential oil

Usual Care

ACTIVE COMPARATOR

Standard procedure, which consists of administering antiemetics if provided in therapy or reporting to the physician with a subsequent treatment decision

Other: Usual Care

Interventions

Lavanda Angustifolia essential oil OTHER

Administration of Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period.

Lavender Yes

Usual Care OTHER

Patients in the Usual Care group will follow the standard procedure, which consists of administering antiemetics if provided in therapy or reporting to the doctor with a subsequent treatment decision

Usual Care

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who sign an informed consent
• Patients who have undergone anesthesiological examination
• Patients undergoing general anaesthesia
• Clinically stable patients
• Patients with nausea scores detected with NRS\>0
• Patients admitted undergoing surgery in the Complex and/or Simple Structures listed below:
• SC of Neurosurgery, undergoing spinal surgery
• SC of General Surgery, undergoing surgery on one of the organs of the abdominal cavity
• SC of Vascular Surgery, undergoing traditional surgical repair or endovascular procedure of abdominal aortic aneurysm. Sclerotherapy (to heal varicose veins) venous stripping (removal of a vein segment in the treatment of varicose veins) laser treatment
• SS of Gynaecological Surgery, undergoing operations on the organs of the female genital apparatus.

You may not qualify if:

• Patients with ongoing relevant cognitive impairment (Six Item Screener score \<4)
• Patients with allergies or sensitivities to lavender essential oils
• Patients with asthma, COPD, Chronic Bronchitis, Obstructive Sleep Apnea
• Patients with changes in sense of smell

Sponsors & Collaborators

• Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria: lead

Study Sites (1)

Clinical Trial Center

Alessandria, Italy, 15121, Italy

Location

MeSH Terms

Conditions

Postoperative Nausea and Vomiting; Nausea; Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Digestive; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Non-pharmacological, single-centre, non-profit, randomised controlled trial.

Study Record Dates

• First Submitted: July 19, 2022
• First Posted: September 16, 2025
• Study Start: November 15, 2022
• Primary Completion: December 31, 2024
• Study Completion: December 15, 2025
• Last Updated: September 16, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)