Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery

NCT06900894 | Completed

• 2 other identifiers: PRF_KT2025Ethics Committee No.
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Conditions

Impacted Third Molar Tooth; Postoperative Pain; Postoperative Edema

Keywords

Impacted third molar; elastic bandage; platelet-rich fibrin; postoperative pain; quality of life; Postoperative Edema

Outcome Measures

Primary Outcomes (3)

• Postoperative Pain Assessment (NRS)

  The pain intensity of the patients will be assessed using the Numerical Rating Scale (NRS) on preoperative day 1 and postoperative days 3 and 7. On this scale: 0 indicates no pain, 10 indicates the worst imaginable pain. Before the procedure, patients were informed about the scale and instructed to rate their pain intensity accordingly.

  Preoperative day 1, postoperative days 3 and 7

• Postoperative Facial Swelling Assessment

  Swelling will be evaluated using anthropometric measurement techniques on preoperative (surgery day), postoperative days 1, 3, and 7. Measurement methods: Lateral canthus-gonion distance (distance from the outer corner of the eye to the mandibular angle) Commissure-tragus distance (distance from the oral commissure to the midpoint of the tragus) All measurements were performed using a flexible ruler, and the results were recorded in millimeters.

  Preoperative day 1, postoperative days 3 and 7

• Oral Health Impact Profile-14 (OHIP-14) Score

  The quality of life of the patients will be assessed using the OHIP-14 questionnaire on postoperative days 3 and 7. OHIP-14 consists of 14 standardized items, each rated on a scale from 0 to 4. Total scores range from 0 to 56, with higher scores indicating worse quality of life. This scale was used to evaluate the impact of postoperative complications on patients' quality of life.

  Postoperative days 3 and 7

Study Arms (3)

PRF Group

EXPERIMENTAL

Participants in this group received Platelet-Rich Fibrin (PRF) applied to the extraction socket following impacted third molar surgery. PRF was prepared using a centrifugation protocol and placed into the surgical site.

Biological: Platelet-Rich Fibrin (PRF)

Kinesio Taping Group

EXPERIMENTAL

Participants in this group received Kinesio Taping applied postoperatively. The elastic therapeutic tape was applied to the masseter and submandibular region following a standardized taping protocol.

Device: Kinesio Taping

Control Group

OTHER

Participants in this group received standard postoperative care, including routine pain management and wound care, without additional interventions.

Other: Standard Postoperative Care

Interventions

Platelet-Rich Fibrin (PRF) BIOLOGICAL

PRF was prepared using a centrifugation protocol and applied to the extraction socket.

PRF Group

Kinesio Taping DEVICE

Kinesio Tape was applied postoperatively to the masseter and submandibular region.

Kinesio Taping Group

Standard Postoperative Care OTHER

Patients in the control group received standard postoperative care.

Control Group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Ages 18-35 years
• Systemically healthy individuals
• Non-smokers
• No psychological disorders
• Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
• No preoperative edema in the surgical area
• Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
• Signed an informed consent form

You may not qualify if:

• Under 18 or over 35 years old
• Presence of chronic or systemic diseases
• Pregnant or breastfeeding patients
• Surgical duration exceeding 45 minutes
• Smokers
• Patients requiring prophylactic antibiotics due to systemic health conditions
• Patients who did not meet the study criteria or did not sign the informed consent form

Sponsors & Collaborators

• Mustafa Kemal University: lead

Study Sites (1)

Hatay Mustafa Kemal University, Faculty of Dentistry

Hatay, 31001, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• züleyha başar karakuzu, DDS

  Mustafa Kemal University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DDS, Oral and Maxillofacial Surgeon

Model Details: This study follows a parallel assignment model in which participants are randomly allocated into three groups: Platelet-Rich Fibrin (PRF), Kinesio Taping, and Control. Each group receives a distinct intervention to evaluate the effectiveness of these non-pharmacological approaches in managing postoperative pain, edema, and recovery following impacted third molar surgery.

Study Record Dates

• First Submitted: March 17, 2025
• First Posted: March 28, 2025
• Study Start: October 1, 2023
• Primary Completion: January 10, 2024
• Study Completion: May 21, 2024
• Last Updated: April 2, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)