Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

NCT06896929 | Not Yet Recruiting Phase 2

• 1 other identifier: 715-24-10-2023ApprovedbyCHUCHS
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Scabies is highly contagious,pruritic infestation of skin.Various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .This randomized clinical trial will be done in children hospital lahore for 12 months.Sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.Then patient will be randomly divided into 3 groups.In group A patient will be given 5% permethrin topical application to whole body single application. In Group B ,patients will be given topical permethrin for twice application 24 hrs appart ,In group C patients will be given Tablet Ivermectin single dose 200microgram/kg.Then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.All this information will be recorded on performa .Data will be entered and analysed by using SPSS version 26.Three groups will be compared for cure by using chi-square test.P value less than and equal to 0.05 will be considered as significant.

Conditions

Scabies

Keywords

Comparison of permethrin and ivermectin in scabies

Outcome Measures

Primary Outcomes (1)

• Cure of scabies.

  Cure will be labeled if greater han 50% reduction in no of lesions and pruritis observed after 4 weeks of treatment.

  12 months

Study Arms (3)

Group A

EXPERIMENTAL

Group A will be given Permethrin

Drug: Permethrin Cream, 5%

Group B

EXPERIMENTAL

Group B will be given Permethrin 5% cream twice application

Drug: Permethrin Cream, 5%

Group C

EXPERIMENTAL

Group C will be given Tab Ivermectin

Drug: Ivermectin 200 µg/kg

Interventions

Permethrin Cream, 5% DRUG

Permethrin 5% cream will be given as a single application

Group A

Ivermectin 200 µg/kg DRUG

Group C will be given Tab Ivermectin

Group C

Eligibility Criteria

• Age: 6 Years - 15 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Age 6-15
• Both genders
• Diagnosed with scabies (as per operational definition)

You may not qualify if:

• Children with recurrent scabies on medical record
• Known allergy to ivermectin or permethrin.
• Widespread eczema or impetigo.
• Liver dysfunction or renal failure

Sponsors & Collaborators

• Children Hospital and Institute of Child Health, Lahore: lead

Study Sites (1)

Children Hospital Lahore

Lahore, Punjab Province, Pakistan

Location

Related Links

• Related Info

MeSH Terms

Conditions

Scabies

Interventions

Ivermectin

Condition Hierarchy (Ancestors)

Mite Infestations; Ectoparasitic Infestations; Skin Diseases, Parasitic; Parasitic Diseases; Infections; Skin Diseases, Infectious; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Macrolides; Polyketides; Lactones; Organic Chemicals

Central Study Contacts

Sadaf Wazir, MBBs

CONTACT

97403284231293; sadaffahad302@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DR SADAF WAZIR

Study Record Dates

• First Submitted: March 20, 2025
• First Posted: March 26, 2025
• Study Start: May 1, 2025
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: April 20, 2025

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)