NCT07247630

Brief Summary

To compare the efficacy of different permethrin-based therapies for scabies infestations in infants and young children.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
68

participants targeted

Target at P75+ for early_phase_1

Timeline
1mo left

Started Jan 2026

Shorter than P25 for early_phase_1

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress75%
Jan 2026Jun 2026

First Submitted

Initial submission to the registry

October 1, 2025

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 25, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

January 15, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 15, 2026

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 15, 2026

Expected
Last Updated

February 3, 2026

Status Verified

February 1, 2026

Enrollment Period

2 months

First QC Date

October 1, 2025

Last Update Submit

February 1, 2026

Conditions

Scabies

Keywords

Permethrin based treatment strategies

Outcome Measures

Primary Outcomes (1)

  • Treatment of scabies

    For efficacy, we will see microscopy (presence of any one by examine skin scraping under a microscope for mites(eyeless and spherical in shape with eight legs parasite)/eggs (oval shape).The absence of these will be considered significant.

    15 days

Secondary Outcomes (2)

  • Scabies

    15 days

  • Scabies

    15 days

Study Arms (2)

Standard permethrin treatment

ACTIVE COMPARATOR

Standard permethrin treatment

Drug: Permethrin 5%

Intensified permethrin treatment

ACTIVE COMPARATOR

Intensified permethrin treatment

Drug: Permethrin 5%

Interventions

Permethrin 5%DRUG

permethrin application

Intensified permethrin treatmentStandard permethrin treatment

Eligibility Criteria

Age1 Month - 4 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • month to 4 years age.
  • Both gender
  • Scabies as defined in operational definition

You may not qualify if:

  • Drug sensitivity test results for hypersensitivity to permethrin
  • Having renal or hepatic impairment.
  • Individuals with additional long-term skin and systemic disorders (such as diabetes, hypertension, asthma, epilepsy, acne, psoriasis)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pak emirates military hospital,Rawalpindi

Rawalpindi, Punjab Province, 00666, Pakistan

Location

MeSH Terms

Conditions

Scabies

Condition Hierarchy (Ancestors)

Mite InfestationsEctoparasitic InfestationsSkin Diseases, ParasiticParasitic DiseasesInfectionsSkin Diseases, InfectiousSkin DiseasesSkin and Connective Tissue Diseases

Central Study Contacts

Shanza zafar, MBBs

CONTACT

+923425316096shanza444@gmail.com

Study Design

Study Type
interventional
Phase
early phase 1
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor

Study Record Dates

First Submitted

October 1, 2025

First Posted

November 25, 2025

Study Start

January 15, 2026

Primary Completion

March 15, 2026

Study Completion (Estimated)

June 15, 2026

Last Updated

February 3, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)