Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients With Hypertensive Angiopathy or Cerebral Amyloid Angiopathy
HA-DN-DPVS
HA-DN-DPVS
Sponsor study identifier
observational
72
1 country
1
Study Start
April 1, 2025
Actual (reported)Primary Completion
December 31, 2025
Actual (reported)Study Completion
December 31, 2025
Actual (reported)Hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA) are the two most common forms of cerebral small vessel disease. On MRI, chronic small vessel disease-related abnormalities include white matter hyperintensities, dilated perivascular spaces (DPVS), lacunar infarction, and hemorrhagic features (e.g. cerebral microbleeds, CMB). In the cerebellum, deep CMB involving the dentate nucleus (DN) is associated with HA, whereas the presence of superficial cerebellar CMB are associated with CAA. DPVS are observed in both diseases, predominant in the subcortical white matter (especially in the centrum semiovale) in CAA whereas HA-related DPVS are predominant deep in the brain inside or nearby the basal ganglia. To the best of our knowledge, DN-DPVS have never been studies systematically in small vessel disease. The researchers want to study DN-DPVS on T2-weighted 3T MRI in patients with HA or CAA and to compare both groups.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2025
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 10, 2025
Actual (reported)March 21, 2025
Actual (reported)April 1, 2025
Actual (reported)December 31, 2025
Actual (reported)December 31, 2025
Actual (reported)Sex
Comparaison of both populations (HA/CAA), H/F
baseline
Hypertension
history of hypertension (Yes/No)
baseline
Age
Age at time of T2-weighted imaging,
baseline
Time
Time between initial MRI-based CAA/HA diagnosis and 3T T2-weighted imaging, axial or coronal views of T2 imaging,
baseline
MRI view
T2 performed using coronal or axial imaging (axial / coronal
baseline
hypercholesterolemia
history of hypercholesterolemia (Yes/No)
baseline
Patients with cerebral amyloid angiopathy
Patients with Hypertensive arteriopathy
Patients with lobar intracerebral hemorrhage \[ICH\], subarachnoid hemorrhage or cortical superficial siderosis for CAA or basal ganglion ICH for HA
CHU de Nîmes
Nîmes, Occitanie, 3029, France
Anissa MEGZARI
Centre Hospitalier Universitaire de Nīmes
72 participants (actual enrollment reported by the registry).
First Submitted
March 10, 2025
First Posted
March 21, 2025
Study Start
April 1, 2025
Actual (reported)Jiedu Huayu Oral Prescription in the Treatment of Intracranial Hemorrhage Associated With Cerebral Amyloid Angiopathy
Hemorrhagic lesion
Hemorrhagic lesion load on T2\*-weighted imaging (ICH and CMB for both CAA and HA, and subarachnoid hemorrhage/cortical superficial siderosis for CAA)
baseline
Subcortical lobar DPVS
Semi-quantitative score for evaluation of subcortical lobar DPVS (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
baseline
DPVS of basal ganglia
Semi-quantitative score for evaluation of DPVS of basal ganglia (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
baseline
Diabete
history of diabetes (Yes/No)
baseline
Smoking
current smoking (Yes / No)
Baseline
Contact the study team to confirm eligibility.
Primary Completion
December 31, 2025
Actual (reported)Study Completion
December 31, 2025
Actual (reported)Last Updated
May 29, 2026
Record last verified: 2026-03
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Source: ClinicalTrials.gov.
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