Detailed Clinical and MRI Characteristics in Primary Non-traumatic Convexity Subarachnoid Haemorrhage Elderly Patients.

NCT04825808 | Completed

• 1 other identifier: Local/2021/DR-01
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Transient focal neurological episode (TFNE) is the most frequent presenting symptom of convexity subarachnoid haemorrhage (cSAH) in elderly patients with non-traumatic cSAH with suspected, possible or probable cerebral amyloid angiopathy (CAA). The aim of our study was to analyse in detail clinical and MRI characteristics in these patients. Methods: We performed a retrospective study analysing baseline, acute clinical symptom (TFNE and headache), and MRI characteristics (acute cSAH and chronic CAA features) of consecutive elderly (≥55 years) patients, recruited and registered in the stroke database, between june 2008 and october 2020 of two centres (Nîmes and Montpellier University Hospital, France), presenting with cSAH with suspected, possible, or probable CAA.

Conditions

Cerebral Amyloid Angiopathy; Subarachnoid Hemorrhage

Outcome Measures

Primary Outcomes (14)

• Description of MRI

  Extent of acute cSAH (number of sulci, focal \[≤3 sulci\] or diffuse \[\>3 sulci\], surface)

  day of the diagnosis

• Description of MRI

  the multifocality of acute cSAH (as described for cortical superficial siderosis (CSS)), sulci involved by cSAH, CSS presence, CSS extent (focal, ≤3 sulci; diffuse \>3 sulci)

  day of the diagnosis

• Description of MRI

  cerebral microbleeds (CMB, \<10 mm) presence

  day of the diagnosis

• Description of MRI

  cerebral microbleeds number

  day of the diagnosis

• Description of MRI

  cerebral microbleeds categorisation (according to the Microbleed Anatomical Rating Scale),

  day of the diagnosis

• Description of MRI

  presence and number of chronic lobar intracerebral haemorrhage (ICH) (\>10 mm)

  day of the diagnosis

• Description of MRI

  Extent of white matter hyperintensities (periventricular Fazekas scale 0-3)

  day of the diagnosis

• Clinical parameters

  Transient focal neurological episode (TFNE) presence

  day of the diagnosis

• Clinical parameters

  number of TFNE preceding MRI

  day of the diagnosis

• Clinical parameters

  TFNE symptoms (sensory, motor, visual, speech; positive or negative symptoms

  day of the diagnosis

• Clinical parameters

  Presence and speed of spreading TFNE symptoms

  day of the diagnosis

• Clinical parameters

  Correlation of TFNE symptoms to cSAH localisation

  day of the diagnosis

• Clinical parameters

  headache (Yes/No)

  day of the diagnosis

• Clinical parameters

  antiepileptic drugs (AED) introduction and type of AED introduced

  day of the diagnosis

Study Arms (1)

Patients

Consecutive elderly (≥55 years) patients, recruited and registered in the stroke database of two centres (Nîmes University Hospital and Montpellier University Hospital, France), presenting with cSAH with suspected, possible, or probable CAA.

Other: usual care

Interventions

usual care OTHER

according to recommendations

Patients

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

consecutive elderly (≥55 years) patients, recruited and registered in the stroke database of two centres (Nîmes University Hospital and Montpellier University Hospital, France), presenting with cSAH with suspected, possible, or probable CAA. The patients were classified as possible or probable CAA according to the modified Boston criteria. Since cortical superficial siderosis (CSS), incorporated in the modified Boston criteria, is probable a result of an earlier acute cSAH, we considered patients with acute cSAH in the absence of other typical CAA-related haemorragic features as patients with suspected CAA.

You may qualify if:

• ≥55 years of age,
• acute symptomatic cSAH based on FLAIR and T2\*-weighted imaging performed within one month of symptom onset, recent trauma,
• anticoagulation treatment, pathological blood coagulation tests (activated partial thromboplastin time \[aPTT\] ratio=patient's aPTT/normal control aPTT\] \>1.2; or partial thromboplastin time \[PTT\] \<75%) or platelet count (\<100 x 109/L),

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (1)

CHU de Nîmes

Nîmes, 30029, France

Location

Related Publications (1)

• Autieri V, Gaillard N, Mourand I, Laurent-Chabalier S, Mura T, Trandafir C, Wacongne A, de Champfleur NM, Thouvenot E, Pereira F, Renard D. Primary acute convexity subarachnoid hemorrhage in older patients: analysis of baseline, clinical and MRI characteristics including quantitative surface study and topographical probabilistic mapping of convexity subarachnoid hemorrhage. Acta Neurol Belg. 2023 Apr;123(2):519-527. doi: 10.1007/s13760-022-02115-8. Epub 2022 Oct 14.

  PMID: 36241843 DERIVED

MeSH Terms

Conditions

Cerebral Amyloid Angiopathy; Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Cerebral Arterial Diseases; Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Amyloidosis; Proteostasis Deficiencies; Metabolic Diseases; Nutritional and Metabolic Diseases; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Anissa MEGZARI

  Centre Hospitalier Universitaire de Nīmes

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 29, 2021
• First Posted: April 1, 2021
• Study Start: February 1, 2021
• Primary Completion: March 29, 2021
• Study Completion: March 29, 2021
• Last Updated: April 1, 2021

Record last verified: 2021-03

Locations

FR (1)