Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France - 3-year Follow-up

NCT06866002 | Not Yet Recruiting DMC

• 1 other identifier: 2024-A02836-41
• Study Type: observational
• Target: 2,011
• Locations: 1 country
• Sites: 1

Brief Summary

Populations in precarious situations or with low socio-economic status are at greater risk of diabetes and accelerated ageing. Depending on the population studied, the factors that may explain these health inequalities are not unequivocal and remain poorly understood. Northern France, which is particularly affected by socio-economic disparities, has one of the highest diabetes prevalence rates in mainland France. This is why the researchers wanted to study the clinical, biological, social and behavioral risk factors for the onset of diabetes and accelerated aging in a large population in northern France. A 2021 study aimed to characterize the population (a majority of whom (55%) suffer from precarious conditions) who came to the Institut Pasteur de Lille for their health check-up, in order to study risk factors to better explain these health inequalities. This research consisted of a descriptive observational cross-sectional study carried out on 2233 volunteers (main group) over 18 months, and a complementary analytical case-control study involving 216 participants (sub-group). At present, we are planning a 3-year follow-up of the cohort. Participants will be recontacted for a new health check-up at the Centre d'examen de Santé de l'Institut Pasteur de Lille. At the end of the health check-up, participants will be interviewed by PrévenDIAB study investigators to collect the same data as initially collected, with the exception of some data we deemed unnecessary.

Conditions

Diabetes; Prediabetes

Keywords

Risk factors; Precarious; Accelerated aging; (Pre) diabetes

Outcome Measures

Primary Outcomes (1)

• fasting blood glucose and Hb1Ac

  Conversion rate of glycemic status (worsening, stable, improving) according to EPICES score. Prevalence of pre-diabetes/diabetes (T0 and T 3 years) according to EPICES score

  Day 0

Secondary Outcomes (4)

• Prevalence ratio of (pre)diabetes calculated for clinical, biological and behavioral/environmental explanatory variables

  Day 0

• Prevalence ratio of (pre) diabetes and accelerated aging according to the socio-economic status

  Day 0

• Risk (odds Ratio) of (pre) diabetes and accelerated aging according to social, economic, cultural and professional status

  Until Day 90

• Risk (odds Ratio) of (pre) diabetes and accelerated aging for assessed exposures

  Until Day 90

Study Arms (2)

Main Group

observational descriptive cohort

Other: Biological analysis, Physical examination and Questionnaires

Sub group

Case control study

Other: Physical examination and Questionnaires

Interventions

Biological analysis, Physical examination and Questionnaires OTHER

Biological analysis, Physical examination and questionnaires will be performed for all patients of the main group.

Main Group

Physical examination and Questionnaires OTHER

In addition to exams for the main group, there will be 2 additional examinations (arterial stiffness) for the patients of the subgroup and others questionnaires.

Sub group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Populations in precarious situations or with low socio-economic status are at greater risk of developing diabetes and of accelerated ageing. Depending on the populations studied, the factors that may explain these health inequalities are not unequivocal and remain poorly understood. The Hauts-de-France region, which is particularly affected by socio-economic disparities, has one of the highest prevalence rates of diabetes in mainland France. That's why we want to study the clinical, biological, social and behavioral risk factors for diabetes onset and accelerated aging in a large population in northern France. Our study aims to characterize the population of consultants at the Centre d'Examens de Santé l'Institut Pasteur de Lille, the majority of whom (55%) suffer from precarious conditions, in order to study the risk factors that may better explain these health inequalities. This population will be monitored every 3 years to assess changes in the various parameters.

You may qualify if:

• Participant in the PrévenDIAB study

You may not qualify if:

• Refusal to participate in study
• Scheduling impossible

Sponsors & Collaborators

• Institut Pasteur de Lille: lead

Study Sites (1)

Institut Pasteur de Lille, Lille

Hauts de France, 59019, France

Location

MeSH Terms

Conditions

Diabetes Mellitus; Prediabetic State; Glucose Intolerance

Interventions

Restraint, Physical; Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hyperglycemia

Intervention Hierarchy (Ancestors)

Behavior Control; Therapeutics; Immobilization; Investigative Techniques; Data Collection; Epidemiologic Methods; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Philippe FROGUEL

  PhD PRECIDIAB

  STUDY CHAIR

• Matthias VANDESQUILLE

  PhD PRECIDIAB

  STUDY DIRECTOR

Central Study Contacts

Frédéric BATTEUX, Pr

CONTACT

0320877316; frederic.batteux@pasteur-lille.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research prevention center manager

Study Record Dates

• First Submitted: March 4, 2025
• First Posted: March 10, 2025
• Study Start: March 5, 2025
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: March 10, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)