Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France

NCT05717491 | Completed DMC

• 1 other identifier: 2021-A01727-34
• Study Type: observational
• Target: 2,014
• Locations: 1 country
• Sites: 1

Brief Summary

Populations in precarious situations or with low socio-economic status have an increased risk of diabetes and accelerated aging. According to the population studied, the elements that can explain these health inequalities are not unequivocal and remain poorly known. The north of France, particularly affected by socio-economic disparities, has a prevalence of diabetes among the highest in metropolitan France. This is why investigators want to study the clinical, biological, social and behavioural risk factors of the entry into diabetes and accelerated aging among a large population in the North of France. This study aims to characterize the population (among which a majority (55%) suffers from precarious conditions) who come to carry out their health examination at the Pasteur Institute in Lille in order to study the risk factors to better explain these health inequalities. This research consists of a main descriptive observational, cross-sectional study carried out on 2233 volunteers (main group) over 18 months, and a complementary analytical case-control study that will be offered to 216 participants (sub-group).

Conditions

Diabetes; PreDiabetes

Keywords

(Pre) diabetes; Risk factors; Precarious; Accelerated aging

Outcome Measures

Primary Outcomes (1)

• Fasting glucose value according to the level of precariousness

  Glycemia in g/L Level of precariousness given by EPICES score

  Day 0

Secondary Outcomes (5)

• Prevalence ratio of (pre)diabetes calculated for clinical, biological and behavioral/environmental explanatory variables

  Day 0

• Assessment of the level of accelerated ageing (DNAmPhenoAge)

  Day 0

• Prevalence ratio of (pre) diabetes and accelerated aging according to the socio-economic status

  Day 0

• Risk (odds Ratio) of (pre) diabetes and accelerated aging according to social, economic, cultural and professional status

  Until Day 90

• Risk (odds Ratio) of (pre) diabetes and accelerated aging for assessed exposures

  Until Day 90

Study Arms (2)

Main group

Cross-sectional study

Other: Biological analysis, Physical examination and Questionnaires

Sub group

Case control study

Other: Physical examination and Questionnaires

Interventions

Biological analysis, Physical examination and Questionnaires OTHER

Biological analysis, Physical examination and questionnaires will be performed for all patients of the main group.

Main group

Physical examination and Questionnaires OTHER

In addition to exams for the main group, there will be 2 additional examinations (bone densitometry and arterial stiffness) for the patients of the subgroup and others questionnaires.

Sub group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Populations in precarious situations or with a low socioeconomic level have an increased risk of entering diabetes and aging accelerated. Depending on the populations studied, the elements that could explain these health inequalities are not unequivocal and are still badly known. The Hauts-de-France region, particularly affected by disparities socio-economic, has one of the most prevalent diabetes high in the metropolis. This is why it's important to study the factors clinical, biological, social and behavioral risks of entry in diabetes and accelerated aging in a large population of North of France. This study aims to characterize the population of the Centre's consultants of Health Examinations at the Institut Pasteur de Lille, of which a majority (55%) suffers from precarious conditions, in order to study the risk factors to better explain these health inequalities.

You may qualify if:

• Adult, male or female
• Consultant for the health prevention examination at the Examination Centre of Health of the Institut Pasteur of Lille
• Available to follow the constraints generated by the study
• Signature of the informed consent
• Status of insured person in France

You may not qualify if:

• Adult deprived of liberty or under judicial protection
• Impediment to give the free and informed consent (understanding, persons under guardianship/curators, etc.)
• Incompatible scheduling
• Other reason (state of health or concomitant treatments,...) considered by the principal investigator or a qualified co-investigator not compatible with the proper conduct of the clinical study

Sponsors & Collaborators

• Institut Pasteur de Lille: lead
• National Center for Precision Diabetic Medicine,PreciDIAB: collaborator

Study Sites (1)

Institut Pasteur de Lille

Lille, Hauts-de-France, 59019, France

Location

Related Links

• National Center for Precision Medicine on Diabetes - PreciDIAB

Biospecimen

Retention: SAMPLES WITH DNA

DNA methylation

MeSH Terms

Conditions

Diabetes Mellitus; Prediabetic State; Glucose Intolerance

Interventions

Restraint, Physical; Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hyperglycemia

Intervention Hierarchy (Ancestors)

Behavior Control; Therapeutics; Immobilization; Investigative Techniques; Data Collection; Epidemiologic Methods; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Philippe Dr FROGUEL, PhD

  PRECIDIAB

  STUDY CHAIR

• Matthias Mr VANDESQUILLE, PhD

  PRECIDIAB

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical director of CPSL

Study Record Dates

• First Submitted: December 14, 2021
• First Posted: February 8, 2023
• Study Start: December 14, 2021
• Primary Completion: March 31, 2024
• Study Completion: March 31, 2024
• Last Updated: April 22, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)