NCT06863727

Brief Summary

The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for disability and cognitive impairment among community-dwelling adults aged 65 years and over. The main question it aims to answer is:

  • What are the high-risk factors able to predict the incidence and advance of disability and cognitive impairment in community-dwelling adults aged 65 years and over?
  • What are the categories of function and cognitive performance trajectory in community-dwelling adults aged 65 years and over?

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,962

participants targeted

Target at P75+ for all trials

Timeline
28mo left

Started Aug 2023

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress55%
Aug 2023Jul 2028

Study Start

First participant enrolled

August 7, 2023

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

February 16, 2025

Completed
19 days until next milestone

First Posted

Study publicly available on registry

March 7, 2025

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2028

Last Updated

March 7, 2025

Status Verified

March 1, 2025

Enrollment Period

5 years

First QC Date

February 16, 2025

Last Update Submit

March 3, 2025

Conditions

AgeingDisabilityCognitive ImpairmentFrailtyIntrinsic Capacity

Keywords

AgeingDisabilityCognitive ImpairmentCommunityCohort

Outcome Measures

Primary Outcomes (3)

  • Disability from the individual's perspective

    Disability is assessed using the 12-item World Health Organization's Disability Assessment Schedule 2.0 (WHODAS 2.0). The WHODAS 2.0 is a patient-reported disability measure, comprising six life domains involving cognition, mobility, self-care, interpersonal relationships, life activities, and participation. The total score of 12-item WHODAS 2.0 categorizes disability from no disability (score 0) to complete disability (score 48).

    An average of 1 to 2 years

  • Disability from the medical's perspective

    Disability is assessed using the basic activities of daily living (BADL) scale, the Katz Index scale. The minimum value is 0 , and the maximum value is 6. The higher the score, the better the outcome.

    An average of 1 to 2 years

  • Disability from the medical's perspective

    Disability is assessed using the instrumental activities of daily living (IADL) scale, the Lawton and Brody IADL scale. The minimum value is 0, and the maximum value is 8. The higher the score, the better the outcome.

    An average of 1 to 2 years

Secondary Outcomes (13)

  • Cognitive impairment

    An average of 1 to 2 years

  • Cognitive impairment

    An average of 1 to 2 years

  • Subjective cognitive decline

    An average of 1 to 2 years

  • Intrinsic capacity

    An average of 1 to 2 years

  • Intrinsic capacity

    An average of 1 to 2 years

  • +8 more secondary outcomes

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Community residents aged 65 years or older in Beijing

You may qualify if:

  • Community-dwelling adults aged 65 years or older who reside in Beijing.
  • Participants who sign an institutionally approved informed consent.

You may not qualify if:

  • Participants with severe mental disorders and serious medical conditions preventing study investigation
  • Participants undergoing long-term professional treatment for physical function and cognitive functioning, such as hospitalization or rehabilitation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Xuanwu Hospital, Capital Medical University

Beijing, 100053, China

RECRUITING

Related Publications (1)

  • Cheng S, Du X, Hou C, Liu H, Lei S, Wu Y, Yue X, Guo Y. Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE): protocol for a community-based prospective longitudinal cohort study about disability prediction model. BMJ Open. 2025 May 15;15(5):e091955. doi: 10.1136/bmjopen-2024-091955.

    PMID: 40379348DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Plan to obtain blood samples from some of the participants

MeSH Terms

Conditions

Cognitive DysfunctionFrailty

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental DisordersPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Yansu Guo, Ph.D

    Beijing Geriatric Healthcare and Disease Prevention Center, Xuanwu Hospital, Capital Medical University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yansu Guo, Ph.D

CONTACT

0086031183973736gys188@163.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 16, 2025

First Posted

March 7, 2025

Study Start

August 7, 2023

Primary Completion (Estimated)

July 31, 2028

Study Completion (Estimated)

July 31, 2028

Last Updated

March 7, 2025

Record last verified: 2025-03

Locations

CN(1)