Regional Distribution Mapping of Lymph Node Metastasis in Epithelial Ovarian Cancer

NCT06853730 | Completed

• 1 other identifier: SYSU-LNM-OVCA01
• Study Type: observational
• Target: 654
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to investigate the metastatic pathways of lymph node involvement in ovarian cancer patients. The main question it aims to answer is: • What are the sequential patterns of lymph node metastasis in ovarian cancer, and are there specific clinical factors associated with different metastatic pathways? Participants diagnosed with ovarian cancer who have undergone lymphadenectomy as part of their standard treatment will have their postoperative pathological lymph node involvement analyzed. The study will retrospectively collect and analyze patient data, including lymph node metastasis patterns, to identify potential progression routes.

Conditions

Ovarian Cancer

Keywords

Lymph Node Metastasis

Outcome Measures

Primary Outcomes (1)

• The incidence of lymph node metastasis in ovarian cancer patients and its association with clinical factors.

  The primary goal of this study is to determine the frequency of lymph node metastasis in patients with ovarian cancer and identify clinical factors associated with the occurrence of metastasis.

  From enrollment to 6 months post-surgery

Study Arms (2)

Non-metastasis Group

This group consists of ovarian cancer patients without lymph node metastasis. By comparing with the metastasis group, we aim to identify the clinical factors that differentiate patients with and without metastasis.

Metastasis Group

This group includes ovarian cancer patients with lymph node metastasis. We will analyze the clinical characteristics and metastasis pathways of these patients to identify clinical factors associated with metastasis.Based on the clinical factors (such as the location of the primary tumor, stage of cancer, etc.), we further subgroup the metastatic patients (e.g., based on the side of the primary tumor). This analysis aims to explore whether there are specific patterns or pathways of lymph node metastasis in these subgroups.

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with epithelial ovarian cancer at the First Affiliated Hospital of Sun Yat-sen University from January 2014 to December 2022 were included in this retrospective study. The inclusion criteria were as follows: i) initial diagnosis and tumor cytoreductive surgery performed at the First Affiliated Hospital of Sun Yat-sen University; ii) confirmed postoperative pathology of epithelial ovarian cancer; iii) available lymph node status; and iv) accessible clinical features, including preoperative ultrasound and blood biochemistry tests. The exclusion criteria were: i) initial diagnosis or surgical treatment conducted at other hospitals; ii) absence of imaging results (CT/PET-CT/MRI) or postoperative pathology results for lymph node status. iii) presence of other cancers; and iv) incomplete medical history

Sponsors & Collaborators

• Xu Huishan: lead

MeSH Terms

Conditions

Ovarian Neoplasms; Lymphatic Metastasis

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders; Neoplasm Metastasis; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Assistant, Ovarian Cancer Study Group, Sun Yat-sen University

Study Record Dates

• First Submitted: February 25, 2025
• First Posted: March 3, 2025
• Study Start: January 1, 2014
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: March 3, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share