NCT06852235

Brief Summary

  1. 1.To assess the frequency, clinical presentation, microbiological and radiological characteristics of liver abscesses.
  2. 2.To evaluate the management plan and treatment outcome of liver abscess.
  3. 3.To study risk factors of liver abscess.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
70

participants targeted

Target at P25-P50 for all trials

Timeline
13mo left

Started Mar 2025

Typical duration for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress52%
Mar 2025Jun 2027

First Submitted

Initial submission to the registry

February 22, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 28, 2025

Completed
15 days until next milestone

Study Start

First participant enrolled

March 15, 2025

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

February 28, 2025

Status Verified

February 1, 2025

Enrollment Period

1.8 years

First QC Date

February 22, 2025

Last Update Submit

February 26, 2025

Conditions

Liver Abscess

Outcome Measures

Primary Outcomes (1)

  • 1. To assess the frequency, clinical picture, microbiological and radiological characteristics of liver abscesses.

    Data will be statistically evaluated by SPSS version 22. Numerical data will be expressed as means ± SDs. Categorical data will be expressed as frequencies (percentages). Comparison between groups will be conducted using t-test or Chi square test as appropriate. P value \<0.05 will be considered as significant.

    Baseline

Secondary Outcomes (2)

  • 2. To evaluate the management plan and treatment outcome of liver abscess.

    Baseline

  • 3. To study risk factors of liver abscess.

    Baseline

Eligibility Criteria

Sexall
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients diagnosed with liver abscess according to inclusion and exclusion criteria.

You may qualify if:

  • Diagnosis of LA will be based on typical appearance on ultrasound (US) or computed tomography (CT) of abdomen with clinical features consistent with the diagnosis (fever, chills, jaundice, right upper quadrant pain/epigastric discomfort).
  • US or CT-guided aspiration of pus from a hepatic lesion.
  • Complete resolution of radiological abnormalities following antimicrobial therapy.

You may not qualify if:

  • Liver abscess that occurs secondary to hydatid cyst.
  • Liver abscess associated with underlying malignancy.
  • Patient with incomplete medical records.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (19)

  • Ahmed S, Chia CL, Junnarkar SP, Woon W, Shelat VG. Percutaneous drainage for giant pyogenic liver abscess--is it safe and sufficient? Am J Surg. 2016 Jan;211(1):95-101. doi: 10.1016/j.amjsurg.2015.03.002. Epub 2015 May 7.

    PMID: 26033361BACKGROUND

  • Alkofer B, Dufay C, Parienti JJ, Lepennec V, Dargere S, Chiche L. Are pyogenic liver abscesses still a surgical concern? A Western experience. HPB Surg. 2012;2012:316013. doi: 10.1155/2012/316013. Epub 2012 Feb 19.

    PMID: 22536008BACKGROUND

  • Baban FA. Clinical characteristic of amoebic liver abscesses in the North of Iraq. Saudi Med J. 2000 Jun;21(6):545-9.

    PMID: 11500703BACKGROUND

  • Ballas ZK, Uthman SM. Amebic liver abscess in Lebanon. A report of 37 cases and a review of the literature. Am J Proctol. 1973 Jun;24(3):228-36. No abstract available.

    PMID: 4707978BACKGROUND

  • Chan KS, Chia CTW, Shelat VG. Demographics, Radiological Findings, and Clinical Outcomes of Klebsiella pneumonia vs. Non-Klebsiella pneumoniae Pyogenic Liver Abscess: A Systematic Review and Meta-Analysis with Trial Sequential Analysis. Pathogens. 2022 Aug 26;11(9):976. doi: 10.3390/pathogens11090976.

    PMID: 36145408BACKGROUND

  • Chiche L, Dargere S, Le Pennec V, Dufay C, Alkofer B. [Pyogenic-liver abscess: diagnosis and management]. Gastroenterol Clin Biol. 2008 Dec;32(12):1077-91. doi: 10.1016/j.gcb.2008.09.019. Epub 2008 Nov 18. French.

    PMID: 19019604BACKGROUND

  • Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.

    PMID: 23353941BACKGROUND

  • Halvorsen RA, Korobkin M, Foster WL, Silverman PM, Thompson WM. The variable CT appearance of hepatic abscesses. AJR Am J Roentgenol. 1984 May;142(5):941-6. doi: 10.2214/ajr.142.5.941.

    PMID: 6372412BACKGROUND

  • Huang CJ, Pitt HA, Lipsett PA, Osterman FA Jr, Lillemoe KD, Cameron JL, Zuidema GD. Pyogenic hepatic abscess. Changing trends over 42 years. Ann Surg. 1996 May;223(5):600-7; discussion 607-9. doi: 10.1097/00000658-199605000-00016.

    PMID: 8651751BACKGROUND

  • Kaplan GG, Gregson DB, Laupland KB. Population-based study of the epidemiology of and the risk factors for pyogenic liver abscess. Clin Gastroenterol Hepatol. 2004 Nov;2(11):1032-8. doi: 10.1016/s1542-3565(04)00459-8.

    PMID: 15551257BACKGROUND

  • Liu L, Chen W, Lu X, Zhang K, Zhu C. Pyogenic Liver Abscess: A Retrospective Study of 105 Cases in an Emergency Department from East China. J Emerg Med. 2017 Apr;52(4):409-416. doi: 10.1016/j.jemermed.2016.09.026. Epub 2016 Oct 17.

    PMID: 27765437BACKGROUND

  • McNeil T, Daniel S, Gordon DL. Management of pyogenic liver abscess: a South Australian experience. ANZ J Surg. 2020 Nov;90(11):2274-2278. doi: 10.1111/ans.15963. Epub 2020 May 26.

    PMID: 32455495BACKGROUND

  • Mohsen AH, Green ST, Read RC, McKendrick MW. Liver abscess in adults: ten years experience in a UK centre. QJM. 2002 Dec;95(12):797-802. doi: 10.1093/qjmed/95.12.797.

    PMID: 12454322BACKGROUND

  • Mousa H, Al-Bluwi GSM, Al Drini ZFM, Gasmelseed HI, Alkoteesh JA, Babiker ZOE. Importation of Entamoeba histolytica and predominance of Klebsiella pneumoniae in liver abscesses: a 7-year retrospective cohort study from the United Arab Emirates. Trop Dis Travel Med Vaccines. 2021 Jun 12;7(1):17. doi: 10.1186/s40794-021-00140-8.

    PMID: 34118991BACKGROUND

  • Mucke MM, Kessel J, Mucke VT, Schwarzkopf K, Hogardt M, Stephan C, Zeuzem S, Kempf VAJ, Lange CM. The role of Enterococcus spp. and multidrug-resistant bacteria causing pyogenic liver abscesses. BMC Infect Dis. 2017 Jun 26;17(1):450. doi: 10.1186/s12879-017-2543-1.

    PMID: 28651522BACKGROUND

  • Nakanishi Y, Kayahara T, Yamashita Y, Okuno M, Nakamura F, Taniguchi Y, Inoue N, Nakatani Y, Hatamaru K, Shimizu T, Tanaka A, Yoshioka T, Seta T, Urai S, Uenoyama Y. [A case of ruptured giant liver cyst complicated by Candida infection]. Nihon Shokakibyo Gakkai Zasshi. 2009 Jul;106(7):1056-62. Japanese.

    PMID: 19578314BACKGROUND

  • Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, O'Neill PJ, Chow AW, Dellinger EP, Eachempati SR, Gorbach S, Hilfiker M, May AK, Nathens AB, Sawyer RG, Bartlett JG. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Surg Infect (Larchmt). 2010 Feb;11(1):79-109. doi: 10.1089/sur.2009.9930.

    PMID: 20163262BACKGROUND

  • Thomsen RW, Jepsen P, Sorensen HT. Diabetes mellitus and pyogenic liver abscess: risk and prognosis. Clin Infect Dis. 2007 May 1;44(9):1194-201. doi: 10.1086/513201. Epub 2007 Mar 28.

    PMID: 17407038BACKGROUND

  • Yoo HM, Kim WH, Shin SK, Chun WH, Kang JK, Park IS. The changing patterns of liver abscess during the past 20 years--a study of 482 cases. Yonsei Med J. 1993 Dec;34(4):340-51. doi: 10.3349/ymj.1993.34.4.340.

    PMID: 8128739BACKGROUND

MeSH Terms

Conditions

Liver Abscess

Condition Hierarchy (Ancestors)

Abdominal AbscessAbscessSuppurationInfectionsLiver DiseasesDigestive System Diseases

Study Officials

  • Ashraf Mahmoud Othman, doctorate

    Assiut University

    STUDY DIRECTOR

  • Haidi Karam-Allah Ramadan, doctorate

    Assiut University

    STUDY DIRECTOR

Central Study Contacts

Marco Magdy, Bachelor

CONTACT

01270777143marcomagdy1997@gmail.com

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Resident at Police Hospital

Study Record Dates

First Submitted

February 22, 2025

First Posted

February 28, 2025

Study Start

March 15, 2025

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

February 28, 2025

Record last verified: 2025-02