Functional Proprioceptive Stimulation and Continuous Passive Motion Rehabilitation Interventions After Anterior Cruciate Ligament Reconstruction

NCT07553013 | Completed

• 1 other identifier: IRB00012476-2025-04-04-397
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this trial is to test if functional proprioceptive stimulations combined with continuous passive movement is more efficient than continuous passive movement alone to recover knee joint mobility after anterior cruciate ligament reconstruction in adults. It will also learn about the influence of functional proprioceptive stimulations on pain and pain medication. The main questions it aims to answer are:

• Does functional proprioceptive stimulations combined with continuous passive movement increase knee joint mobility more than continuous passive movement alone?
• Does functional proprioceptive stimulations combined with continuous passive movement reduce perceived pain and pain medication use more than continuous passive movement alone? Researchers will compare functional proprioceptive stimulations combined with continuous passive movement to continuous passive movement alone to see if functional proprioceptive stimulations combined with continuous passive movement is more efficient than continuous passive movement alone. Participants will:
• Follow a supervised rehabilitation intervention comprising functional proprioceptive stimulations combined with continuous passive movement or continuous passive movement alone during five days a week for 2 weeks
• Attend the clinic five days a week for 2 weeks for rehabilitation, checkups and assessments

Conditions

Anterior Cruciate Ligament Reconstruction Rehabilitation

Outcome Measures

Primary Outcomes (1)

• Active and passive range of motion

  Active and passive range of motion of the knee joint (in degrees; °) will be assessed with a 30-cm long manual goniometer at the end of the first session, the fifth and the last rehabilitation session of the 2 weeks intervention.

  From enrollment to the end of intervention at 2 weeks

Secondary Outcomes (1)

• Perceived pain and pain medication

  Throughout the 2 weeks intervention

Study Arms (2)

functional proprioceptive stimulations combined with continuous passive movement

EXPERIMENTAL

Device: functional proprioceptive stimulations combined with continuous passive movement; Device: continuous passive movement

continuous passive movement

ACTIVE COMPARATOR

Device: continuous passive movement

Interventions

functional proprioceptive stimulations combined with continuous passive movement DEVICE

5 days a week for 2 weeks

functional proprioceptive stimulations combined with continuous passive movement

continuous passive movement DEVICE

5 days a week for 2 weeks

continuous passive movement; functional proprioceptive stimulations combined with continuous passive movement

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• participants with isolated ACL rupture
• ACL reconstructed with a four-stranded semitendinosus or ex-tra-articular tenodesis autograft
• enrollment in the rehabilitation program between the fourth and seventh postoperative day

You may not qualify if:

• previous ligament reconstruction of the involved knee, reconstruction using quadriceps or patellar tendon autograft
• presence of major neurological or musculoskeletal disorders (e.g., multiple trauma, Parkinson's disease, cerebral palsy, stroke, Alzheimer's disease, dementia…)
• presence of cognitive impairment (i.e., Mini Mental State Examination score \< 18)
• body mass index greater than 35 kg/m².

Sponsors & Collaborators

• Universite Cote d'Azur: lead

Study Sites (1)

Clinique Saint-Martin Sport

Marseille, 13000, France

Location

MeSH Terms

Interventions

Motion Therapy, Continuous Passive

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Musculoskeletal Manipulations

Study Officials

• Serge S Colson, Professor

  Universite Cote d'Azur

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: April 27, 2026
• Study Start: June 16, 2025
• Primary Completion: October 24, 2025
• Study Completion: October 24, 2025
• Last Updated: April 27, 2026

Record last verified: 2026-04

Locations

FR (1)