Acute Myocardial Infarction - Allied Health-Oriented Patient-centered Digitally-Enabled Care

NCT07443982 | Active Not Recruiting

• 1 other identifier: PHRGTC-0003
• Study Type: interventional
• Target: 1,633
• Locations: 1 country
• Sites: 6

Brief Summary

The Acute Myocardial Infarction - allied Health Oriented, Patient centered, and digitally Enabled care (AMI-HOPE) program is a model of care designed to improve post-AMI well-being, safety, and outcomes through greater involvement of AHPs in patient care and integrating digital technologies into routine primary care disease management. AMI-HOPE aims to deliver solutions to these identified gaps of care which will transform healthcare planning both at cluster and national levels. The cornerstone of the AMI-HOPE program will be upskilling pharmacists to take on low-intermediate complexity clinician roles during the post-discharge period. The first 6 months will be anchored by tertiary care before a handoff to primary care. This frees up cardiologists to focus on high complexity cases.

Conditions

Acute Myocardial Infarction (AMI)

Outcome Measures

Primary Outcomes (1)

• Death and Unplanned Cardiovascular Disease (CVD) related (non-fatal MI, non-fatal stroke, others) rehospitalizations

  Counts and time to any events of death or unplanned CVD related rehospitalizations

  between enrolment and end of 12-month follow up

Secondary Outcomes (11)

• Absolute change in concentration of Low-Density Lipoprotein Cholesterol (LDL-C)

  between enrolment and end of 12-month follow up

• Change in Blood Pressure (BP)

  At discharge, 2 week, 1, 3, 6, 9 &12 months

• Change in Haemoglobin A1c (HbA1c)

  between enrolment and end of 12-month follow up

• EuroQoL (Quality of Life)-5 Dimensions (EQ-5D) Scores in Participants

  At 1 month and 12 month

• Patient Activation Measure (PAM-13) Scores in Participants

  At discharge and 6month

Other Outcomes (1)

• Cost-effectiveness

  At the end of 12-month follow up

Study Arms (2)

Control

OTHER

Standard of Care

Other: Standard of Care (SOC)

Pharmacist-led digital platform assisted care

OTHER

AMI-HOPE centers around a digital platform that offers continuous telemonitoring on patients' vitals, tailored medication prescription with support from pharmacists, and personalised lifestyle nudges and educational material.

Other: Pharmacist-led digital platform assisted care

Interventions

Standard of Care (SOC) OTHER

Standard of care treatment without the pharmacist-led digital platform assisted care

Control

Pharmacist-led digital platform assisted care OTHER

Up titration of medications by pharmacist. AMI-HOPE centers around a digital platform that offers continuous telemonitoring on patients' vitals, tailored medication prescription with support from pharmacists and personalised lifestyle nudges and educational material.

Pharmacist-led digital platform assisted care

Eligibility Criteria

• Age: 21 Years - 90 Years
• Gender Eligibility Details: Male and Female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or Female, aged 21 to 90 years (inclusive), at the time of signing the informed consent form
• Clinically diagnosed with AMI during index hospitalisation
• Own a mobile phone with internet access- intervention arm only

You may not qualify if:

• Patients who are planned for palliative care or life expectancy \<1 year
• Foreigners who do not have Singaporean citizenship/ Permanent Resident (PR) status
• Patients who are enrolled into Healthier SG affiliated with General Practitioners (GPs)
• Allergy or intolerance of Angiotensin-Converting Enzyme Inhibitors (ACE-I) or Angiotensin II Receptor Blockers (ARB)

Sponsors & Collaborators

• National University Heart Centre, Singapore: lead

Study Sites (6)

Changi General Hospital (CGH)

Singapore, Singapore

Location

Khoo Teck Puat Hospital (KTPH)

Singapore, Singapore

Location

National Heart Centre Singapore (NHCS)

Singapore, Singapore

Location

National University Heart Centre, Singapore (NUHCS)

Singapore, Singapore

Location

Ng Teng Fong General Hospital (NTFGH)

Singapore, Singapore

Location

Tan Tock Seng Hospital (TTSH)

Singapore, Singapore

Location

MeSH Terms

Interventions

Standard of Care

Intervention Hierarchy (Ancestors)

Quality Indicators, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation

Study Officials

• Mark Chan

  National University Heart Centre, Singapore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Executive Director and Senior Consultant, National University Heart Centre

Model Details: Step Wedge Trial

Study Record Dates

• First Submitted: February 1, 2026
• First Posted: March 2, 2026
• Study Start: January 11, 2023
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: March 2, 2026

Record last verified: 2026-02

Locations

SG (6)