Combination of Vebreltinib and Osimertinib in Patients with EGFR 21 L858R Mutation Advanced NSCLC

NCT06827145 | Active Not Recruiting Phase 2

• 1 other identifier: NCC4728
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This is a Prospective, open label, single arm study to evaluate the efficacy and safety of Vebreltinib combined with Osimertinib in the treatment of locally advanced or metastatic non-small cell lung cancer with EGFR 21 L858R mutation

Conditions

Non-Small-Cell Lung Cancer

Keywords

NSCLC; EGFR; Vebreltinib

Outcome Measures

Primary Outcomes (1)

• Progression-free survival

  From the first treatment to the date of first documentation of disease progression, or death due to any cause

  3 years

Secondary Outcomes (4)

• Overall Response Rate

  3 years

• Overall survival

  5 years

• Duration of Response

  3 years

• Incidence of Treatment-Emergent Adverse Events

  3 years

Study Arms (1)

Experimental Arm

EXPERIMENTAL

All patients received oral Vebreltinib 100mg BID plus Osimertinib 80mg once daily.

Drug: Vebreltinib; Drug: Osimertinib

Interventions

Vebreltinib DRUG

Vebreltinib 100mg oral BID

Also known as: PLB1001, Bozitinib

Experimental Arm

Osimertinib DRUG

Osimertinib 80mg oral once daily.

Experimental Arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \. Signed an informed consent form.
• \. Patients aged ≥18.
• \. Histologically or cytologically confirmed locally or metastatic NSCLC.
• EGFR 21 L858R mutation.
• at least one measurable lesion according to RECIST 1.1 criteria.
• ECOG PS 0-1.
• appropriate organ function.
• For female subjects of reproductive age, a urine or serum pregnancy test should be performed negative within 7 days prior to receiving the first study drug administration .If there is a risk of conception, all subjects (male or female) must agree to use effective contraception from the time they sign an informed consent until 3 months after the final administration of the study drug.
• The expected survival is more than 3 months.

You may not qualify if:

• Patients with EGFR 19del mutation , ALK or ROS1 gene fusions.
• \. Patients with symptomatic, neurologically unstable central nervous system (CNS) metastases, or CNS diseases that require increased steroid doses to control.
• Previous treatment history meets one of the following criteria: 1)prior treated with systemic treatment. 2)The last administration of other anti-tumor drugs was less than 14 days or 5 half-life period before the initiation of study agents. 3)Received traditional Chinese medicine with anti-tumor indications within 1 week prior to initiation of treatment, 4)Thoracic radiotherapy to lung fields (including whole brain radiotherapy) ≤4 weeks prior to initiation of study treatment , for all other sites (except lung and whole brain) ≤2 weeks prior to initiation of study treatment. 5)Received major surgery within the past 4 weeks, or received resection of brain metastatic lesion within 2 weeks, or the side effects of such surgery have not yet been recovered.
• Previous anti-tumor therapy toxicity have not been recovered to ≤ Grade 1 (NCI-CTCAE 5.0) or baseline, except for alopecia, skin pigmentation and grade 2 peripheral neurotoxicity.
• Receive a potent inducer and/or potent inhibitor of CYP3A4 within 1 week prior to initiation of study drug or need receive a potent inducer and/or potent inhibitor of CYP3A4 during the study period.
• Any serious or uncontrolled systemic disease, including, but not limited to, other serious or psychiatric disorders or laboratory abnormalities, in which the investigator determines that the study drug is not suitable for the patient or affects protocol adherence.
• Cardiac function and disease meet one of the following criterias: QTc \> 470 ms, Severe cardiac arrhythmia; Any risk factors that increase the length of the QTc; New York College of Cardiology (NYHA) Heart function grade ≥3. Poorly controlled hypertension.
• Have a history of interstitial lung disease, drug-induced interstitial lung disease, or radiation pneumonia requiring steroid therapy, or are currently receiving drug therapy or other clinical interventions, or have existing active interstitial lung disease.
• A history of thromboembolic or venous thromboembolic events (including myocardial infarction, cerebrovascular event or transient ischemic attack, pulmonary embolism, deep vein thrombosis, or any other severe thromboembolic event) in the 6 months prior to the initial study drug administration, Any life-threatening bleeding event (including treatment requiring blood transfusion, surgery or local treatment, and ongoing medication) was judged to have a bleeding tendency.
• Active gastrointestinal disorders (such as ulcerative lesions, uncontrolled nausea, vomiting, diarrhea, and malabsorption syndrome) or other conditions (such as inability to swallow the investigational agent, or prior major gastrointestinal surgery) may significantly affect the absorption, distribution, metabolism, or excretion of the oral investigational agent.
• Any systemic disease that the investigator determines to require treatment .
• A history of acute or chronic pancreatitis, pancreatic surgery, or risk factors that may increase the risk of developing pancreatitis.
• Active infection, including but not limited to:infected with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) (HIV antibody positive), infected with syphilis, active tuberculosis, the presence of active infections (such as pneumonia) requiring systematic anti-infective therapy within 2 weeks before drug administration in the first study.
• Patients being treated with warfarin or any other anticoagulant, except low-dose warfarin (\< 2 mg) for the prevention of central catheter-associated thrombosis;
• Participants with known hypersensitivity or contraindications to study drug of same class or any excipient of these agents.

Sponsors & Collaborators

• National Cancer Center, China: lead
• Avistone Biotechnology Co., Ltd.: collaborator

Study Sites (1)

Cancer insititue and Hospital of CHINESE ACADEMY OF MEDICAL SCIENCE

Beijing, China

Location

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

osimertinib

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctorate

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: February 14, 2025
• Study Start: October 14, 2024
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2028
• Last Updated: February 14, 2025

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)