Success Metrics

Clinical Success Rate
75.6%

Based on 34 completed trials

Completion Rate
76%(34/45)
Active Trials
99(56%)
Results Posted
82%(28 trials)
Terminated
11(6%)

Phase Distribution

Ph phase_2
77
44%
Ph phase_1
55
31%
Ph phase_3
22
12%
Ph phase_4
3
2%
Ph early_phase_1
1
1%
Ph not_applicable
3
2%

Phase Distribution

56

Early Stage

77

Mid Stage

25

Late Stage

Phase Distribution161 total trials
Early Phase 1First-in-human
1(0.6%)
Phase 1Safety & dosage
55(34.2%)
Phase 2Efficacy & side effects
77(47.8%)
Phase 3Large-scale testing
22(13.7%)
Phase 4Post-market surveillance
3(1.9%)
N/ANon-phased studies
3(1.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.3%

34 of 47 finished

Non-Completion Rate

27.7%

13 ended early

Currently Active

99

trials recruiting

Total Trials

177

all time

Status Distribution
Active(113)
Completed(34)
Terminated(13)
Other(17)

Detailed Status

Active, not recruiting51
Recruiting48
Completed34
unknown16
Not yet recruiting14
Terminated11

Development Timeline

Analytics

Development Status

Total Trials
177
Active
99
Success Rate
75.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.6%)
Phase 155 (34.2%)
Phase 277 (47.8%)
Phase 322 (13.7%)
Phase 43 (1.9%)
N/A3 (1.9%)

Trials by Status

not_yet_recruiting148%
recruiting4827%
terminated116%
withdrawn21%
active_not_recruiting5129%
suspended11%
unknown169%
completed3419%

Recent Activity

Clinical Trials (177)

Showing 20 of 177 trialsScroll for more
NCT06618287Phase 1

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Recruiting
NCT05401110Phase 1

Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

Recruiting
NCT04181060Phase 3

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Recruiting
NCT06014827Phase 2

Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma

Recruiting
NCT06350097Phase 3

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

Recruiting
NCT05642572Phase 2

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

Recruiting
NCT07375316Phase 2

A ctDNA-guided Phase II Trial of Osimertinib in Combination With Sacituzumab Tirumotecan in EGFR-mutated Advanced NSCLC Patients With Positive ctDNA After lead-in Osimertinib Monotherapy

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT05624996Phase 3

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Recruiting
NCT07329322Phase 2

Phase II Study of Sacituzumab Tirumotecan in Combination With Osimertinib or Sacituzumab Tirumotecan for Neoadjuvant Treatment in Patients With Resectable Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Recruiting
NCT03191149Phase 2

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

Recruiting
NCT03586453Phase 2

Osimertinib In EGFR Mutant Lung Cancer

Active Not Recruiting
NCT03122717Phase 1

Osimertinib and Gefitinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer

Active Not Recruiting
NCT02664935Phase 2

National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

Completed
NCT02971501Phase 2

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

Active Not Recruiting
NCT06630325Phase 2

A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer

Terminated
NCT05017025Phase 1

Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer

Active Not Recruiting
NCT03778229Phase 2

Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib

Active Not Recruiting
NCT05120349Phase 3

A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection

Active Not Recruiting
NCT04487080Phase 3

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
177