Success Metrics

Clinical Success Rate
76.6%

Based on 36 completed trials

Completion Rate
77%(36/47)
Active Trials
100(54%)
Results Posted
81%(29 trials)
Terminated
11(6%)

Phase Distribution

Ph early_phase_1
1
1%
Ph phase_4
3
2%
Ph not_applicable
3
2%
Ph phase_2
81
44%
Ph phase_1
56
30%
Ph phase_3
24
13%

Phase Distribution

57

Early Stage

81

Mid Stage

27

Late Stage

Phase Distribution168 total trials
Early Phase 1First-in-human
1(0.6%)
Phase 1Safety & dosage
56(33.3%)
Phase 2Efficacy & side effects
81(48.2%)
Phase 3Large-scale testing
24(14.3%)
Phase 4Post-market surveillance
3(1.8%)
N/ANon-phased studies
3(1.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

73.5%

36 of 49 finished

Non-Completion Rate

26.5%

13 ended early

Currently Active

100

trials recruiting

Total Trials

185

all time

Status Distribution
Active(118)
Completed(36)
Terminated(13)
Other(17)

Detailed Status

Active, not recruiting53
Recruiting47
Completed36
Not yet recruiting18
unknown16
Terminated11

Development Timeline

Analytics

Development Status

Total Trials
184
Active
100
Success Rate
76.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.6%)
Phase 156 (33.3%)
Phase 281 (48.2%)
Phase 324 (14.3%)
Phase 43 (1.8%)
N/A3 (1.8%)

Trials by Status

completed3620%
active_not_recruiting5329%
not_yet_recruiting1810%
withdrawn21%
recruiting4726%
suspended11%
unknown169%
terminated116%

Recent Activity

Clinical Trials (185)

Showing 20 of 185 trialsScroll for more
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03191149Phase 2

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

Recruiting
NCT03831932Phase 1

Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer

Active Not Recruiting
NCT07738172Phase 3

Osimertinib With or Without Primary Lung Tumor Resection for EGFR-Mutant Oligometastatic Non-Small Cell Lung Cancer

Not Yet Recruiting
NCT02496663Phase 1

Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

Active Not Recruiting
NCT04181060Phase 3

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Recruiting
NCT06507306Phase 1

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Active Not Recruiting
NCT06618287Phase 1

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Recruiting
NCT05142189Phase 1

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

Recruiting
NCT06477055

The Recurrence Gene Profiles of Adjuvant Osimertinib Therapy in Resected Non-Small-Cell Lung Cancer

Completed
NCT02971501Phase 2

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

Active Not Recruiting
NCT06194448Phase 2

To Evaluate the Efficacy/Safety of Osimertinib Prior to CRT and Maintenance of it With Stage III, Unresectable NSCLC With EGFR Mutations

Active Not Recruiting
NCT04285671Phase 1

Necitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung Cancer

Active Not Recruiting
NCT07680790Phase 3

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

Not Yet Recruiting
NCT07669779Phase 2

A Phase II Study of AK146D1 in Combination With AK112 in Advanced Non-Small Cell Lung Cancer

Recruiting
NCT03381274Phase 1

Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study

Active Not Recruiting
NCT03940703Phase 2

A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)

Active Not Recruiting
NCT07535437Phase 1

A Study of Ivonescimab in Combination With Dato-DXd or Osimertinib in People With Non-Small Cell Lung Cancer

Recruiting
NCT06670196Phase 3

A Study of SKB264 in Combination With Osimertinib Versus Osimertinib in Patients With Epidermal Growth Factor Receptor (EGFR) Mutations, Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Active Not Recruiting
NCT05629234Phase 3

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
185