Identification of Microplastics in Liver, Stomach, Blood, and Feces of Obese Patients and Their Association Analysis with Macrogenomics and Metabolomics.

NCT06826586 | Active Not Recruiting DMC

• 1 other identifier: 2025-099-01
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the association between obesity and visceral microplastics, and to investigate the effects of microplastics on the visceral microbiota and metabolic profiles of obese patients by combining the macro-genomic and metabolomics approaches.

Conditions

Obesity and Overweight

Keywords

microplastics; obesity; macro-genomic; metabolomics

Outcome Measures

Primary Outcomes (1)

• Differences in microbial communities

  Differences in different microbial communities in the stomach, liver, feces, and blood of obese patients

  From the diagnosis of obesity, through study completion, an average of 1 year.

Study Arms (1)

obesity group

BMI≧30

Diagnostic Test: Measuring the microplastics

Interventions

Measuring the microplastics DIAGNOSTIC_TEST

Measuring the type, nature, and abundance of microplastics in stomach, liver, feces, and blood

obesity group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients diagnosed with obesity

You may qualify if:

• Age ≥18 years old;
• BMI ≧30;
• proposed to undergo bariatric surgery and need to remove part of the liver tissue for fatty liver test;
• complete clinical data and basic information;
• willing to participate in the study and sign the informed consent form.

You may not qualify if:

• Receive chemotherapy, radiotherapy, immunotherapy;
• have other history of digestive diseases;
• combined with malignant tumors;
• have serious cardiorespiratory insufficiency and other systemic diseases that affect the choice of treatment plan;
• not willing to participate in this study.

Sponsors & Collaborators

• First Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

MeSH Terms

Conditions

Obesity; Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: February 14, 2025
• Study Start: December 1, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: February 14, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)