The Effects of Environmental Factors on the Macro-genome and Metabolism of Obese Patients.

NCT06673433 | Active Not Recruiting DMC

• 1 other identifier: 202-331-01
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The present study was designed to include obese patients diagnosed with obesity in the First Affiliated Hospital of Chongqing Medical University and a healthy control population. By analysing the relationship between metabolic parameters and macrogenomes in obesity, identifying key metabolic and macrogenomic differences between obese patients and healthy populations, and establishing the association between environmental factors and obesity-related metabolic disorders, the investigators will be able to provide new biomarkers and intervention targets for obesity prevention and treatment.

Conditions

Obesity and Overweight

Keywords

obesity; environment; air pollution; macrogenomics; metabolism

Outcome Measures

Primary Outcomes (1)

• BMI

  BMI = weight / height squared (kg/m2)

  BMI was examed when first join the study, whith through the whole study period, an average of 1 month.

Study Arms (2)

the obesity group

Patients diagnosed with obesity (body mass index (BMI) ≥ 28kg/m2)

Diagnostic Test: obesity

the control group

Paticipants with nomal BMI （18.5 - 24 kg/m2)

Diagnostic Test: health

Interventions

obesity DIAGNOSTIC_TEST

Patients diagnosed with obesity (BMI ≥ 28kg/m2)

the obesity group

health DIAGNOSTIC_TEST

the health control group include paticipants with nomal BMI

the control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study intend to include patients diagnosed with obesity in the First Hospital of Chongqing Medical University.

You may qualify if:

• Age ≥18 years;
• Obese patients with BMI ≥30kg/m2;
• Patients did not undergo surgical treatment before enrolment;
• Willing to participate in this study and sign the informed consent form;
• Complete clinical data.

You may not qualify if:

• Patients with systemic diseases such as severe cardiorespiratory insufficiency that affect the choice of treatment regimen;
• Pregnant or lactating women;
• Patients who are not suitable for enrolment as assessed by the investigator;
• Patients with incomplete clinical data.

Sponsors & Collaborators

• Dong Peng: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

MeSH Terms

Conditions

Obesity; Overweight

Interventions

Adiposity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Body Fat Distribution; Body Weights and Measures; Body Constitution; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Body Composition; Biochemical Phenomena; Chemical Phenomena; Metabolism; Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 2, 2024
• First Posted: November 4, 2024
• Study Start: October 1, 2022
• Primary Completion: August 1, 2025
• Study Completion: December 1, 2025
• Last Updated: June 2, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)