The Ventilation During In-hospital Cardiac Arrest Study
VENT-IHCA
The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study
3 other identifiers
observational
900
2 countries
11
Brief Summary
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients. The main questions it aims to answer are: What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC? Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2025
Typical duration for all trials
11 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 20, 2025
CompletedStudy Start
First participant enrolled
February 1, 2025
CompletedFirst Posted
Study publicly available on registry
February 5, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 1, 2027
March 30, 2026
March 1, 2026
2.2 years
January 20, 2025
March 27, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Fraction of patients with return of spontaneous circulation (ROSC)
ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.
ROSC is assessed immediately following cardiopulmonary resuscitation.
Secondary Outcomes (1)
Fraction of patients surviving until day 30
Assessed at day 30 after cardiac arrest.
Other Outcomes (3)
Fraction of patients with pulmonary complications
From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days.
Number of days alive without mechanical ventilation
From date of ROSC until day 30 or date of death from any cause, whichever came first.
Number of days alive outside the intensive care unit
From date of ROSC until day 90 or date of death from any cause, whichever came first.
Study Arms (1)
Study cohort
Adult patients (≥18 years) with in-hospital cardiac arrest receiving cardiopulmonary resuscitation. Groups will be defined based on observed distribution of ventilation parameters (ventilation rate, tidal volume and minute ventilation).
Interventions
The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.
Eligibility Criteria
Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.
You may qualify if:
- In-hospital cardiac arrest
- Age ≥ 18 years
- \>1minute of recorded ventilation data
You may not qualify if:
- Documented do-not-attempt cardiopulmonary resuscitation order
- Invasive mechanical circulatory support at the time of the cardiac arrest
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (11)
Hospital of Southern Jutland - Aabenraa
Aabenraa, Denmark
Aalborg University Hospital
Aalborg, 9000, Denmark
Aarhus University Hospital
Aarhus, 8200, Denmark
Hospital of Southwest Jutland - Esbjerg
Esbjerg, 6700, Denmark
Gødstrup Hospital
Gødstrup, 7400, Denmark
North Denmark Region Hospital - Hjørring
Hjørring, 9800, Denmark
Horsens Regional Hospital
Horsens, 8700, Denmark
Odense University Hospital
Odense, 5000, Denmark
Randers Regional Hospital
Randers, 8930, Denmark
Viborg Regional Hospital
Viborg, 8800, Denmark
St. Olavs Hospital, Trondheim University Hospital
Trondheim, 7006, Norway
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Johannes Wittig, MD
Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark
- PRINCIPAL INVESTIGATOR
Kasper G Lauridsen, MD, PhD
Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 20, 2025
First Posted
February 5, 2025
Study Start
February 1, 2025
Primary Completion (Estimated)
April 1, 2027
Study Completion (Estimated)
June 1, 2027
Last Updated
March 30, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will not share
The investigators are not permitted to share IPD.