Effect of Exercise on MiR-126 in Individuals With Prediabetes

NCT06809257 | Completed

• 2 other identifiers: EMiR-126-PDSaglik Bilimleri University
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.

Conditions

Prediabetes; microRNA; Exercise

Keywords

MiR-126; Exercise; Prediabetes; MicroRNA

Outcome Measures

Primary Outcomes (1)

• Delta CT mir-126

  Ct (cycle threshold) values for miR-126 and miR-16-5p were used for analysis. ΔCt and ΔΔCt values were calculated as follows, and expression levels were analyzed using the 2-ΔΔCt method: ∆Ct = Ct (gene of interest) - Ct (housekeeping gene) ΔΔCt = ∆Ct (treated sample) - ∆Ct (untreated sample) Higher ΔCt values indicate lower expression levels.

  1 week

Secondary Outcomes (1)

• BMI

  1 day

Study Arms (2)

Exercise

ACTIVE COMPARATOR

Individuals in the intervention group were included in a planned aerobic exercise program for 12 weeks.This program was carried out under the supervision of specialist doctors, with the help of sports trainers and physiotherapists, and participants were given 60 minutes of moderate-intensity (50-70% of their maximum heart rate) aerobic exercise three days a week.

Behavioral: Exercise

Control

NO INTERVENTION

No intervention

Interventions

Exercise BEHAVIORAL

12 week moderately aerobik exercise

Exercise

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Individuals who were newly diagnosed with prediabetes according to the Oral Glucose Tolerance Test (OGTT) and/or HbA1C criteria
• between the ages of 18-60
• were physically inactive (Level 1 according to the International Physical Activity Questionnaire)
• were motivated to exercise
• Individuals who had no obstacle to exercise as a result of the evaluation made by a cardiologist (ECG, exercise ECG test, etc.)
• and who did not show a change in body weight of more than ±2.5 kg in the last six months were included in the study.

You may not qualify if:

• presence of serious medical conditions (e.g. advanced cancer, major neurological or endocrine disorders, respiratory failure)
• current cardiovascular disease, BMI \<19 kg/m²
• history of metformin use within the last 6 months
• receiving hormone replacement therapy
• life expectancy less than one year
• HIV positivity
• substance use
• or orthopedic and cognitive disorders that may prevent exercise

Sponsors & Collaborators

• Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey: lead

Study Sites (1)

Sultan 2. Abdülhamid Han Training and Research Hospital

Üsküdar, Istanbul, 34660, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Prediabetic State; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Elif Yıldırım Ayaz

  Sultan 2. Abdülhamid Han Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Dr.

Study Record Dates

• First Submitted: January 23, 2025
• First Posted: February 5, 2025
• Study Start: May 1, 2021
• Primary Completion: April 30, 2023
• Study Completion: April 30, 2023
• Last Updated: February 5, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)