Effectiveness of Video-Based Upper Extremity Exercise Program in Parkinson's Disease

NCT06807411 | Completed

• 1 other identifier: E-10840098-202.3.02-2282
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Over the past decade, virtual reality (VR) has been widely recognized as a therapeutic tool that enables neurological patients to interact with simulated environments through multiple sensory channels. Various sensors can be used in VR systems, with Nintendo Wii and Microsoft Kinect being the most popular. Video game-based training, grounded in VR technology, has emerged as a valid, cost-effective, and easily integrated adjunct to conventional therapy in neurorehabilitation. Compared to traditional exercise methods, video game training offers advantages by allowing users to perform physical activities in a safe and controlled environment. However, some studies have reported limited effects, emphasizing the need for more high-quality research to establish the effectiveness of interactive video games in neurological rehabilitation. This study aims to investigate the effects of a video-based game exercise program targeting the upper extremity in individuals with Parkinson's disease on joint range of motion, proprioception, functionality, postural instability due to kyphotic posture, and quality of life.

Conditions

Parkinson Disease; Exercise; Exergame; Therapy

Keywords

parkinson; exergame; serious game; exercise; physiotherapy

Outcome Measures

Primary Outcomes (4)

• Balance

  The Becure Balance System will be used to assess participants' postural stability. During this measurement, the participant will be asked to place both feet on the Balance Board and maintain balance for 15 seconds. Throughout this period, the participant's sway movements will be recorded.

  From enrollment to the end of treatment at 8 weeks

• Joint position sense

  The Becure Extremity ROM device will be used to assess proprioception in participants at 30° and 60° shoulder flexion and abduction positions. Participants will first be asked to raise their shoulder to a specified angle, then replicate the same angle with their eyes closed. The angle values recorded with eyes open and closed will be compared, and the difference between the shoulder angles will be calculated.

  From enrollment to the end of treatment at 8 weeks

• Range of motion

  joint range of motion (ROM) will be assessed using the Becure Extremity ROM system. This system utilizes built-in cameras and sensors to detect reference points during extremity movements, allowing for an objective measurement of joint ROM. In the Becure Extremity ROM assessment, the participant will stand in front of the camera and perform the required movement. Shoulder joint ROM, including flexion, extension, abduction, internal rotation, and external rotation, will be measured in degrees using this system.

  From enrollment to the end of treatment at 8 weeks

• Functionality

  Participants' upper extremity functionality will be assessed using the DASH (Disabilities of the Arm, Shoulder, and Hand) Questionnaire. DASH is designed to measure physical disability and symptoms in individuals with upper extremity disorders (hand, wrist, elbow, and shoulder). It is a 30-item scale that evaluates difficulties in performing various physical activities requiring upper extremity function.

  From enrollment to the end of treatment at 8 weeks

Secondary Outcomes (1)

• Parkinson's Disease Questionnaire (PDQ-39)

  From enrollment to the end of treatment at 8 weeks

Study Arms (2)

Conventional exercise group

ACTIVE COMPARATOR

Participants in the conventional exercise group will undergo 24 sessions over 8 weeks (3 days per week, 30-minute sessions). The program will include: Stretching, strengthening, balance, gait, and posture exercises for the trunk and extremities. Kyphosis prevention exercises, including pectoral stretching, back extensor strengthening, and trunk mobilization. Resistance training using sandbags, dumbbells, and elastic bands. Tandem walking, weight-shifting on a balance board, and Frenkel coordination exercises. Each exercise will be performed for 15 repetitions, while stretching exercises will follow a 20-second stretch and 20-second rest protocol. Progression will be customized based on the participant's condition.

Other: Conventional exercise

Video game based exercise group

EXPERIMENTAL

Participants will be randomly assigned to either a conventional exercise group or a video-based game exercise group. All participants will receive conventional therapy for 8 weeks, 3 days per week, with 30-minute sessions (24 sessions in total). The video-based game exercise group will undergo the same conventional therapy, with an additional video game-based exercise program using the Becure Extremity ROM device under physiotherapist supervision. The program will include KinectPong, KinectBalloon, ArmRotate, and Uball games. Balance, joint position sense, ROM, functionality, and quality of life parameters will be assessed before and after treatment.

Other: Video game based exercise

Interventions

Conventional exercise OTHER

Participants in the conventional exercise group will receive a total of 24 sessions of conventional therapy over 8 weeks (3 days per week, 30-minute sessions).

Conventional exercise group

Video game based exercise OTHER

The video-based game exercise group will undergo the same conventional therapy, with an additional video game-based exercise program using the Becure Extremity ROM device under physiotherapist supervision. The program will include KinectPong, KinectBalloon, ArmRotate, and Uball games. Balance, joint position sense, ROM, functionality, and quality of life parameters will be assessed before and after treatment.

Video game based exercise group

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals aged 50-80 with idiopathic Parkinson's disease
• Hoehn and Yahr Scale Stage I to III
• Presence of kyphotic posture

You may not qualify if:

• Presence of any other neurological condition
• Any pathology affecting the movement system in addition to Parkinson's disease
• Visual abnormalities
• Cardiovascular conditions that may interfere with treatment
• Dyskinesia
• History of surgery for Parkinson's disease
• Inability to cooperate at a level required to play the games

Sponsors & Collaborators

• Istanbul Medipol University Hospital: lead

Study Sites (1)

Istanbul Medipol University

Istanbul, Beykoz, 34810, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Parkinson Disease; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Behavior

Study Officials

• Burak Menek, PhD

  Medipol University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 29, 2025
• First Posted: February 4, 2025
• Study Start: February 3, 2025
• Primary Completion: July 5, 2025
• Study Completion: July 12, 2025
• Last Updated: November 17, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)