LHC-CIDI-5 in Hong Kong

NCT06804525 | Recruiting

• 2 other identifiers: UW 24-7712024-0089-004
• Study Type: observational
• Target: 2,500
• Locations: 1 country
• Sites: 1

Brief Summary

The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10). However, retrospective measurements like the CIDI-5 are susceptible to recall bias, especially for the lifetime experience, which can hinder the reporting accuracy with mental disorders. To mitigate this issue, the life history calendar (LHC) was introduced as an aid to assist respondents in recalling the timing of life events, enhancing the ability of the CIDI-5 to measure the lifetime prevalence of mental disorders. The LHC is a grid structure with columns representing time units and rows representing life domains under study. In a study conducted in Nepal, combining the CIDI-5 with the LHC resulted in a significant increase in the detection of mental disorders compared to using the CIDI-5 alone. This approach did not lead to an increase in false positives after clinical validation. This experiment aims to adapt a Hong Kong version of the LHC based on the Nepalese model and evaluate the effectiveness of the LHC-assisted CIDI-5 (LHC-CIDI-5) compared to the CIDI-5 alone in assessing mental disorders.

Conditions

Persistent Depressive Disorder (PDD); Suicidal Ideation; Suicidal Plan; Suicidal Attempt; Suicidal Gesture; Nonsuicidal Self-Injury; Manic Episode; Hypomanic; Bipolar I Disorder; Bipolar Sub Disorder; Bipolar II Disorder; Generalized Anxiety Disorder (GAD); Intermittent Explosive Disorder (IED); Panic Attack; Panic Disorder; Obsessive-Compulsive Disorder (OCD); Posttraumatic Stress Disorder (PTSD); PCL-SC PTSD; PCL-5 PTSD; Alcohol Use Disorder (AUD); Substance Use Disorder (SUD); Major Depressive Episode (MDE); Major Depressive Disorder (MDD)

Keywords

Life History Calendar; CIDI; Recall bias; Retrospective reporting; Lifetime prevalence; Mental disorders

Outcome Measures

Primary Outcomes (10)

• Depression

  The main outcomes in this module are the lifetime prevalence of Major Depressive Episode (MDE) and Major Depressive Disorder (MDD)

  Immediately following intervention or recruitment

• Persistent Depression

  The main outcome in this module is the lifetime prevalence of Persistent Depressive Disorder (PDD)

  Immediately following intervention or recruitment

• Self Harm

  The main outcomes in this module are the lifetime prevalence of Suicidal Ideation, Suicidal Plan, Suicidal Attempt, Suicidal Gesture, and Nonsuicidal Self-Injury.

  Immediately following intervention or recruitment

• High Mood

  The main outcomes in this module are the lifetime prevalence of Manic Episode, Hypomanic, Bipolar I Disorder, Bipolar Sub Disorder, and Bipolar II Disorder

  Immediately following intervention or recruitment

• Worry and Anxiety

  The main outcome in this module is the lifetime prevalence of Generalized Anxiety Disorder (GAD)

  Immediately following intervention or recruitment

• Anger Attacks

  The main outcome in this module is the lifetime prevalence of Intermittent Explosive Disorder (IED)

  Immediately following intervention or recruitment

• Panic Attacks

  The main outcomes in this module are the lifetime prevalence of Panic Attack and Panic Disorder.

  Immediately following intervention or recruitment

• Obsessions and Compulsions

  The main outcome in this module is the lifetime prevalence of Obsessive-Compulsive Disorder (OCD)

  Immediately following intervention or recruitment

• Stressful Experiences

  The main outcomes in this module are the lifetime prevalence of Posttraumatic Stress Disorder (PTSD), PCL-SC PTSD, and PCL-5 PTSD.

  Immediately following intervention or recruitment

• Tobacco, Alcohol, and Drugs

  The main outcomes in this module are the lifetime prevalence of Alcohol Use Disorder (AUD) and Substance Use Disorder (SUD)

  Immediately following intervention or recruitment

Study Arms (2)

CIDI-5

For the CIDI-5 group, respondents will directly partake in the CIDI-5 interview without responding to any inquiries regarding their life history.

Diagnostic Test: CIDI-5

LHC-CIDI-5

For the LHC-CIDI-5 group, respondents, before initiating the CIDI-5, will begin with LHC, completing a calendar by answering questions about important personal experiences since birth until the interview year.

Diagnostic Test: LHC-CIDI-5

Interventions

CIDI-5 DIAGNOSTIC_TEST

The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10) . Trained interviewers will administrate selected modules from the Hong Kong version of the CIDI-5 in a computer-assisted personal interview to measure the outcomes.

CIDI-5

LHC-CIDI-5 DIAGNOSTIC_TEST

The interviewer will start by asking the respondent's age and significant personal experiences, which is expected to take 15 minutes. Remembering and recording the experiences provide cognitive engagement and information which can further serve as memory cues for respondents in the following screening of CIDI-5. Subsequently, the respondents will proceed to the screening section for CIDI-5 and will refer to the completed calendar from the LHC section when they are asked to report lifetime experience or age-of-onset for mental disorders. Trained interviewers will conduct all interviews in a computer-assisted personal interview. To validate the diagnoses in the LHC-CIDI-5 group, clinical re-interviews for MDD, GAD, and PTSD will be conducted by a trained mental health professional with previous experience using DSM-5.

LHC-CIDI-5

Eligibility Criteria

• Age: 25 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study is a sub-study of the District Health Profile (DHP), which is a district-level representative descriptive cross-sectional study. In DHP, 1% of households in selected Hong Kong districts will be randomly selected from the Census and Statistics Department's list of quarters, with stratification based on districts and housing types; all persons aged 18 and above in the recruited households will be included and surveyed. For participants who consent to join the DHP study, a sub-sample of 2,500 participants aged 25 or above will be randomly selected and assigned to two groups through a random process. All 2,500 individuals will complete the survey for the DHP study, including the CIDI-5 section. When administering the CIDI-5, one group of 1,250 individuals will be interviewed using only the CIDI-5, while the other group of 1,250 individuals will be interviewed with LHC first, followed by the CIDI-5.

You may qualify if:

• All household members aged 25 years old and over are randomly sampled from the Census and Statistics Department List of Quarters
• Live in the address sampled from the Census and Statistics Department List of Quarters
• Reside in Hong Kong for at least six months in the past year
• Able to read and communicate in Chinese or English
• Without linguistic or cognitive difficulties

You may not qualify if:

• Domestic workers

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

The University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

Related Publications (2)

• Amro I, Ali A, Hassan MHMO, Al Shawwaf M, Alhassan A, Al Bahari D, El Fakki H, Hijawi Z, Aly S, Amin A, Mohammed R, Nofal M, Abdelkader M, Salman S, Currie J, Alabdulla M, Sampson NA, First M, Kessler RC, Woodruff PW, Khaled SM. Design and field procedures for the clinical reappraisal of the Composite International Diagnostic Interview version 3.3 in Qatar's national mental health study. Int J Methods Psychiatr Res. 2023 Sep;32(3):e1958. doi: 10.1002/mpr.1958. Epub 2023 Jan 18.

  PMID: 36654500 BACKGROUND

• Axinn WG, Chardoul S, Gatny H, Ghimire DJ, Smoller JW, Zhang Y, Scott KM. Using life history calendars to improve measurement of lifetime experience with mental disorders. Psychol Med. 2020 Feb;50(3):515-522. doi: 10.1017/S0033291719000394. Epub 2019 Mar 11.

  PMID: 30854987 BACKGROUND

MeSH Terms

Conditions

Depressive Disorder, Major; Suicidal Ideation; Self-Injurious Behavior; Mania; Bipolar Disorder; Generalized Anxiety Disorder; Disruptive, Impulse Control, and Conduct Disorders; Panic Disorder; Obsessive-Compulsive Disorder; Stress Disorders, Post-Traumatic; Alcoholism; Substance-Related Disorders; Mental Disorders

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Suicide; Behavioral Symptoms; Behavior; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Bipolar and Related Disorders; Anxiety Disorders; Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Alcohol-Related Disorders; Chemically-Induced Disorders

Study Officials

• Michael Y. Ni, MD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yoona Kim, PhD

CONTACT

852+39179109; yoonak@hku.hk

Rusi Long, MHS

CONTACT

852+39102308; rlong36@hku.hk

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: January 24, 2025
• First Posted: February 3, 2025
• Study Start: January 18, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: March 10, 2026

Record last verified: 2026-03

Locations

HK (1)