Major Depressive Disorder (MDD)
168
53
62
53
Key Insights
Highlights
Success Rate
91% trial completion (above average)
Published Results
15 trials with published results (9%)
Research Maturity
53 completed trials (32% of total)
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 40/100
3.0%
5 terminated out of 168 trials
91.4%
+4.9% vs benchmark
19%
32 trials in Phase 3/4
28%
15 of 53 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 53 completed trials
Clinical Trials (168)
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
Home-Based tDCS for Depression in BPD
Identification and Molecular Characterisation of Urban-environmental Stress Patterns Affecting Mental Illness
IWLS for Major Depressive Disorder: An Open-Label Study of Safety, Tolerability, and Efficacy
Preventing Relapse After Successful Electroconvulsive Therapy for Depression
A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Inhaled DMT for Major Depressive Disorder
Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in the Diagnosis and Treatment Outcomes of Severe Mental Disorders
Sedation and Guided Education for Depression Study
A Study of SEP-380135 in Adults With Schizophrenia or Major Depressive Episode
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole
Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS)
Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression