Effect of Turner Syndrome on Number Sense

NCT03459651 | Withdrawn

• 1 other identifier: 092883
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates approximate number sense (ANS) in children, adolescents, and adult women with Turner syndrome compared to age-matched healthy peers. One primary aim of this project is to assess the effectiveness of an online ANS training tool in enhancing complex mathematics ability. Participants will undergo weekly training sessions in their own home. Half of the participants will complete 2 training sessions a week for 8 weeks, and the second half will complete 1 training session for 8 weeks.

Conditions

Turner Syndrome

Keywords

numeracy; number sense

Outcome Measures

Primary Outcomes (2)

• Single and multiple-operand addition and subtraction accuracy

  Task accuracy calculated as the percentage of trials answered correctly.

  8 weeks

• Single and multiple-operand addition and subtraction response time

  Average amount of time, in seconds, required to answer each question on the task.

  8 weeks

Study Arms (1)

ANS training

EXPERIMENTAL

Behavioral: ANS training

Interventions

ANS training BEHAVIORAL

In-home computer-based ANS training

ANS training

Eligibility Criteria

• Age: 6 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Children, adolescents, and adult women with Turner syndrome.
• Healthy controls.
• Normal or corrected to normal vision.

You may not qualify if:

• Major psychiatric or developmental disorder (e.g., bipolar disorder, major depression, psychotic disorders, intellectual disability, autism spectrum disorder).
• Chemical dependency
• Currently taking the following medications: antidepressant, antipsychotic, and anti-seizures drugs.

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Center for Interdisciplinary Brain Sciences Research

Stanford, California, 94305, United States

Location

MeSH Terms

Conditions

Turner Syndrome

Condition Hierarchy (Ancestors)

Gonadal Dysgenesis; Disorders of Sex Development; Urogenital Abnormalities; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Sex Chromosome Disorders of Sex Development; Male Urogenital Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Sex Chromosome Disorders; Chromosome Disorders; Genetic Diseases, Inborn; Gonadal Disorders; Endocrine System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Instructor

Study Record Dates

• First Submitted: February 27, 2018
• First Posted: March 9, 2018
• Study Start: April 1, 2022
• Primary Completion: April 2, 2022
• Study Completion: April 2, 2022
• Last Updated: May 9, 2022

Record last verified: 2022-05

Locations

US (1)