Stroke Volume at Rest and During Exercise in Healthy Volunteers

NCT07318844 | Completed DMC

• 1 other identifier: H-25024676
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Background Changes in cardiac output, driven by increased heart rate and stroke volume, are crucial for oxygen delivery during acute exercise and influence maximal oxygen uptake (VO₂max). Thoracic electrical bioimpedance provides a non-invasive alternative to traditional invasive methods by estimating stroke volume through impedance changes during ventricular filling and emptying. However, its test-retest reliability remains uncertain, requiring further investigation for use in acute and long-term training assessments. Methods Inclusion: 12 healthy individuals (six males, six females) Exclusion: Known ischaemic heart disease, known heart failure, symptoms of disease within 2 weeks prior to the study, known malignant disease, claudication, pregnancy, unstable cardiac arrhythmic disease, renal or liver dysfunction, known chronic lung disease Design: Test-retest study of thoracic electrical bioimpedance-based stroke volume Intervention: Acute exercise bout on a bicycle ergometer Statistical design: Rest-to-exercise changes, as well as between-day smallest real difference, coefficient of variation and intraclass correlation coefficient Sample size: Since this is a pilot study, the sample size is set at 12 in accordance with current recommendations. Perspective The results are relevant for designing future studies in which stroke volume is measured and compared in response to various interventions at rest and during exercise.

Conditions

Healthy

Keywords

stroke volume; test-retest; Acute exercise

Outcome Measures

Primary Outcomes (2)

• Between-day smallest real difference (SRD) for stroke volume during upright rest

  2-10 days

• Between-day coefficient of variance (CV) for for stroke volume during upright rest

  2-10 days

Secondary Outcomes (4)

• Between-day smallest real difference (SRD) for stroke volume during supine rest

  2-10 days

• Between-day coefficient of variance (CV) for stroke volume during supine rest

  2-10 days

• Between-day SRD for stroke volume at 60% of maximal workload (Wmax) during CPET

  2-10 days

• Between-day CV for stroke volume at 60% of Wmax during CPET

  2-10 days

Other Outcomes (52)

• Between-day SRD for stroke volume at 40% of Wmax during CPET

  2-10 days

• Between-day CV for stroke volume at 40% of Wmax during CPET

  2-10 days

• Between-day SRD for stroke volume at 80% of Wmax during CPET

  2-10 days

Study Arms (1)

Exercise bout

EXPERIMENTAL

A cardiopulmonary exercise test (CPET), during which stroke volume and heart rate are continuously measured

Other: Cardiopulmonary exercise test

Interventions

Cardiopulmonary exercise test OTHER

The two study days are identical, and consist of stroke volume, heart rate and non-invasive blood pressure measurements during upright rest, in the supine position, and during incremental exercise (CPET).

Exercise bout

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women
• years

You may not qualify if:

• Known chronic lung disease
• Known ischaemic heart disease
• Known heart failure
• Symptoms of disease within 2 weeks prior to the study
• Known malignant disease
• Claudication
• Pregnancy
• Unstable cardiac arrhythmic disease
• Renal or liver dysfunction

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead

Study Sites (1)

Trygfondens Center for Aktiv Sundhed

Copenhagen, 2100, Denmark

Location

MeSH Terms

Interventions

Exercise Test

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, MD DMSc

Study Record Dates

• First Submitted: August 31, 2025
• First Posted: January 6, 2026
• Study Start: September 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: January 6, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)