Epidemiology of Abdominal Aortic Aneurysm With Concomitant Primary Lung Cancer
1 other identifier
observational
2,000
1 country
2
Brief Summary
Retrospective clinical case studies in recent years have shown that most cases of lung cancer and abdominal aortic aneurysm (AAA) are detected at the same time and that there is a wide variation in the prevalence of AAA in patients with primary lung cancer reported in the literature, with some papers suggesting as high as 11%, suggesting that there may be a relationship between the prevalence of the two diseases. However, its exact incidence and mechanism are unknown. Accurate prevention of AAA in patients with primary lung cancer requires more in-depth studies. To solve the above problems, a multi-center prospective epidemiological investigation and mechanism study on the association of AAA in primary lung cancer combined has become particularly urgent. The results of the study will be of great significance for the follow-up treatment and prognosis of lung cancer patients as well as the improvement of long-term survival rate of lung cancer patients, and will also provide scientific basis and clinical guidance for the screening and prevention of AAA in lung cancer patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2022
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2022
CompletedFirst Submitted
Initial submission to the registry
May 19, 2024
CompletedFirst Posted
Study publicly available on registry
January 15, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2025
CompletedJanuary 15, 2025
January 1, 2025
2.6 years
May 19, 2024
January 11, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incidence of abdominal aortic aneurysm in patients with primary lung cancer
Incidence of abdominal aortic aneurysm in patients with primary lung cancer
2022-10-01 to 2025-04-30
Secondary Outcomes (1)
Epidemiological analysis
2022-10-01 to 2025-04-30
Study Arms (1)
Primary lung cancer with concomitant abdominal aortic aneurysm
Interventions
Patient underwent ultrasound or CT of the abdominal aorta
Eligibility Criteria
The selected subjects for the study were all patients diagnosed with primary lung cancer at the First Affiliated Hospital of Kunming Medical University and the Third Affiliated Hospital of Kunming Medical University from 1st October 2022 to 30 st April 2025, with an estimated sample size of about 2000 people. Detailed epidemiological data and long-term follow-up data were collected and analyzed, and epidemiological investigations were conducted.
You may qualify if:
- Patients diagnosed with primary lung cancer through clinical or pathological examination
You may not qualify if:
- Patients diagnosed with primary lung cancer who refuse to undergo abdominal aortic imaging screening.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650000, China
The Third Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650000, China
Related Publications (11)
Sakalihasan N, Michel JB, Katsargyris A, Kuivaniemi H, Defraigne JO, Nchimi A, Powell JT, Yoshimura K, Hultgren R. Abdominal aortic aneurysms. Nat Rev Dis Primers. 2018 Oct 18;4(1):34. doi: 10.1038/s41572-018-0030-7.
PMID: 30337540BACKGROUNDSchanzer A, Oderich GS. Management of Abdominal Aortic Aneurysms. N Engl J Med. 2021 Oct 28;385(18):1690-1698. doi: 10.1056/NEJMcp2108504. No abstract available.
PMID: 34706173BACKGROUNDGolledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019 Apr;16(4):225-242. doi: 10.1038/s41569-018-0114-9.
PMID: 30443031BACKGROUNDAlnahhal KI, Urhiafe V, Narayanan M, Irshad A, Salehi P. Prevalence of abdominal aortic aneurysms in patients with lung cancer. J Vasc Surg. 2022 May;75(5):1577-1582.e1. doi: 10.1016/j.jvs.2021.09.037. Epub 2021 Oct 8.
PMID: 34634421RESULTWiles B, Comito M, Labropoulos N, Santore LA, Bilfinger T. High prevalence of abdominal aortic aneurysms in patients with lung cancer. J Vasc Surg. 2021 Mar;73(3):850-855. doi: 10.1016/j.jvs.2020.05.069. Epub 2020 Jul 2.
PMID: 32623102RESULTCho HJ, Yoo JH, Kim MH, Ko KJ, Jun KW, Han KD, Hwang JK. Risk of various cancers in adults with abdominal aortic aneurysms. J Vasc Surg. 2023 Jan;77(1):80-88.e2. doi: 10.1016/j.jvs.2022.03.896. Epub 2022 Jul 15.
PMID: 35850163RESULTHohneck A, Shchetynska-Marinova T, Ruemenapf G, Pancheva M, Hofheinz R, Boda-Heggemann J, Sperk E, Riffel P, Michels J, Borggrefe M, Akin I, Sigl M. Coprevalence and Incidence of Lung Cancer in Patients Screened for Abdominal Aortic Aneurysm. Anticancer Res. 2020 Jul;40(7):4137-4145. doi: 10.21873/anticanres.14413.
PMID: 32620663RESULTHarthun NL, Lau CL. The incidence of pulmonary neoplasms discovered by serial computed tomography scanning after endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2011 Mar;53(3):738-41. doi: 10.1016/j.jvs.2010.09.066. Epub 2010 Dec 3.
PMID: 21129909RESULTLederlin M, Tredaniel J, Priollet P. [Why screen for lung cancer in patients with arterial disease?]. J Mal Vasc. 2015 Dec;40(6):359-64. doi: 10.1016/j.jmv.2015.07.001. Epub 2015 Aug 12. French.
PMID: 26276562RESULTErbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwoger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ; ESC Committee for Practice Guidelines. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J. 2014 Nov 1;35(41):2873-926. doi: 10.1093/eurheartj/ehu281. Epub 2014 Aug 29. No abstract available.
PMID: 25173340RESULTScorza R, Ghilardi G, De Monti M, Sgroi G. [Current knowledge and unresolved problems in the pathogenesis of abdominal aortic aneurysm]. Minerva Cardioangiol. 1994 Sep;42(9):417-27. Italian.
PMID: 7991161RESULT
Biospecimen
Fresh AAA samples, fresh Ca lung samples, with organ donors normal aorta and lung tissue.
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Xu-Dong Xiang, MPhil
The Third Affiliated Hospital of Kunming Medical University
- STUDY DIRECTOR
Ding-yun You, Ph.D.
Kunming Medical University
- STUDY DIRECTOR
Yun-fei Shi, MPhil
First Affiliated Hospital of Kunming Medical University
- PRINCIPAL INVESTIGATOR
Gui-ming Liu, MBBS
The Third Affiliated Hospital of Kunming Medical University
- PRINCIPAL INVESTIGATOR
Qing-yan Ma, MBBS
Kunming Medical University
- PRINCIPAL INVESTIGATOR
Qian Zhu, MBBS
The Third Affiliated Hospital of Kunming Medical University
- STUDY CHAIR
Kai-xiong Qing, ph.D.
The Third Affiliated Hospital of Kunming Medical University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
May 19, 2024
First Posted
January 15, 2025
Study Start
October 1, 2022
Primary Completion
April 30, 2025
Study Completion
April 30, 2025
Last Updated
January 15, 2025
Record last verified: 2025-01