Prognostic Impact of NLR, PLR, and MPV in Patients Undergoing AAA Open Repair

NCT05031195 | Completed

• 1 other identifier: 3-2020-0479
• Study Type: observational
• Target: 334
• Locations: 1 country
• Sites: 1

Brief Summary

Abdominal aortic aneurysm (AAA) is a multifactorial degenerative disorder, which if untreated might lead to catastrophic complications. The treatment for AAA includes open and endovascular repair, both of which carry a significant degree of risk. Thus, researchers have performed several studies addressing simple and readily available risk stratification markers, such as complete blood count in patients undergoing open AAA repair. The neutrophil to lymphocyte ratio (NLR) has been frequently used as a marker of systemic inflammatory response, which reflects neutrophilia and lymphopenia. The primary pathophysiology of AAA involves chronic inflammation in the aortic wall and atherosclerosis, accompanied with thrombosis. NLR was proposed as a fair indicator for poor prognosis in patients with AAA. The mean platelet volume (MPV) is the marker of platelet activation and an indicator of the activation of thrombus formation. Moreover, it is reportedly associated with the prognosis of patients with cardiovascular diseases. Moreover, the platelet to lymphocyte ratio (PLR) suggests thrombosis and inflammation and indicates a high risk of cardiovascular events in various groups of patients. The PLR is associated with poor prognosis following AAA repair. Despite accumulating evidence for the prognostic value of white blood cell counts in abdominal aortic aneurysm, few studies have investigated the value of these parameters, including NLR, MPV, and PLR, in patients undergoing AAA open repair. The investigators aimed to investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair.

Conditions

Abdominal Aortic Aneurysm

Keywords

neutrophil to lymphocyte ratio; platelet to lymphocyte ratio; mean platelet volume; aortic surgery; abdominal aortic aneurysm.

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative 1-yr mortality

  The incidence of postoperative 1-yr mortality in patients undergoing open repair of abdominal aortic aneurysm.

  1-yr after operation

Study Arms (3)

1st tertile

Other: 1st tertile, 2nd tertile, 3rd tertile

2nd tertile

Other: 1st tertile, 2nd tertile, 3rd tertile

3rd tertile

Other: 1st tertile, 2nd tertile, 3rd tertile

Interventions

1st tertile, 2nd tertile, 3rd tertile OTHER

Patients will be divided into 3 groups according to the preoperative NLR value.

1st tertile; 2nd tertile; 3rd tertile

Eligibility Criteria

• Age: 19 Years - 99 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing open AAA repair in university hospital.

You may qualify if:

• patients who underwent open repair of abdominal aortic aneurysm.

You may not qualify if:

• patients with previous aortic repair within 6 months.
• mycotic aneurysm.
• iliac artery aneurysm.
• aorta occlusive disease.
• incomplete data.

Sponsors & Collaborators

• Gangnam Severance Hospital: lead

Study Sites (1)

Gangnam Severance Hospital

Seoul, South Korea

Location

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 29, 2021
• First Posted: September 1, 2021
• Study Start: January 11, 2020
• Primary Completion: March 30, 2021
• Study Completion: March 30, 2021
• Last Updated: March 25, 2022

Record last verified: 2022-03

Locations

KR (1)