Speed of Glucose Absorption During Exercise

NCT06768333 | Completed

• 1 other identifier: LMS-24-Dean-2
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to look at how fast commercially available supplements containing carbohydrates can get into the bloodstream during repeated sprint cycles. This will build from a pervious study where the investigators tested these supplements on healthy participants during a resting oral glucose tolerance trial. The investigators will be testing three supplements, namely Voom Pocket Rocket, SIS Go Isotonic Energy Gel, and Maurten Gel 160. Each participant will complete all three conditions, consuming one of each supplement at random per condition. The study requires participation from male and female runners, cyclists and triathletes who are aged between 18-40. Each visit will take approximately 1 hour, and three experimental visits per participant. The study will involve frequent blood sampling and the continuous monitoring of gas exchange (oxygen/carbon dioxide). Blood sampling via cannulation will be used to analyse the lactate, glucose, and electrolyte content of the blood. Gas exchange will measure the oxygen breathed in and carbon dioxide breathed out throughout the exercise. The investigators plan to carry out the study on 10 participants who will be a mix of male and female runners, cyclists and triathletes.

Conditions

Healthy Nutrition; Healthy

Outcome Measures

Primary Outcomes (3)

• Blood Glucose

  Frequent blood sampling for blood glucose (1ml after every stage of both sprint cycling and active recovery) followed by analysis in the Biosen Analyser

  Blood glucose measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery

• Blood Lactate

  Frequent blood sampling for blood lactate (1ml after every stage of both sprint cycling and active recovery) followed by analysis in the Biosen Analyser

  Blood lactate measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery

• Gas Exchange

  Gas exchange measured throughout each 20 minute exercise via a Cortex Metalyzer

  Gas exchange will be measured continuously throughout the 20 minutes of exercise, starting at the warmup

Secondary Outcomes (3)

• Blood electrolyte content

  Blood electrolyte measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery

• Rate of Percieved exertion (RPE)

  RPE will be measured at the end of the warmup and the end of the final sprint stage

• Gastrointestinal (GI) Discomfort Questionnaire

  GI Discomfort will be measured 5 minutes before and 5 minutes after exercise

Study Arms (3)

Voom Pocket Rocket Electro Energy Bar

EXPERIMENTAL

After at least 48 hours, every participant will undergo a different condition

Dietary Supplement: 45 grams Voom Pocket Rocket Electro Energy

Maurten Gel 160

EXPERIMENTAL

After at least 48 hours, every participant will undergo a different condition

Dietary Supplement: 45 grams Maurten Gel 160

SIS Go Isotonic Energy Gel

EXPERIMENTAL

After at least 48 hours, every participant will undergo a different condition

Dietary Supplement: 45 grams SIS Go Isotonic Energy Gel

Interventions

45 grams Voom Pocket Rocket Electro Energy DIETARY_SUPPLEMENT

Participants will be required to consume 45 grams (in carbohydrates) of the Voom Pocket Rocket Electro Energy on one of the three experimental visits. Participants will have blood glucose, blood lactate, and electrolytes sampled throughout five 15-second repeated cycling intervals interspersed with 3 minutes active recovery. Gas exchange will also be monitored throughout the 1-hour study visit.

Voom Pocket Rocket Electro Energy Bar

45 grams Maurten Gel 160 DIETARY_SUPPLEMENT

Participants will be required to consume 45 grams (in carbohydrates) of the Maurten Gel 160 on one of the three experimental visits. Participants will have blood glucose, blood lactate, and electrolytes sampled throughout five 15-second repeated cycling intervals interspersed with 3 minutes active recovery. Gas exchange will also be monitored throughout the 1-hour study visit.

Maurten Gel 160

45 grams SIS Go Isotonic Energy Gel DIETARY_SUPPLEMENT

Participants will be required to consume 45 grams (in carbohydrates) of the SIS Go Isotonic Energy Gel on one of the three experimental visits. Participants will have blood glucose, blood lactate, and electrolytes sampled throughout five 15-second repeated cycling intervals interspersed with 3 minutes active recovery. Gas exchange will also be monitored throughout the 1-hour study visit.

SIS Go Isotonic Energy Gel

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: Males and Females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 18-40 years
• Male or female
• Tier 2 athletes - local level representation, training \~ 3 times per week, training with a purpose to compete, identify with a specific sport, limited skill development (McKay et al., 2021)

You may not qualify if:

• Allergies to any listed ingredients on any supplements.
• Diabetes (type 1 or 2)
• Any medical conditions
• Smokers
• Any injury that would prevent them from exercising
• Anyone using drugs or medication (not including contraception)
• Anyone consuming alcohol within 24 hours of the study
• Exercise must be restricted within 24 hours of the study
• Caffeine must not be consumed within 24 hours of testing as it can significantly enhance carbohydrate oxidation rates (Yeo et al., 2005)
• Diets including high-carbohydrate-low-fat (HCLF), low-carbohydrate-high-fat (LCHF), ketogenic, and/or glycogen manipulation diets (Rauch et al., 2022)

Sponsors & Collaborators

• Lancaster University: lead

Study Sites (1)

Lancaster University

Lancaster, Lancashire, LA1 4AT, United Kingdom

Location

Related Publications (1)

• Rauch CE, McCubbin AJ, Gaskell SK, Costa RJS. Feeding Tolerance, Glucose Availability, and Whole-Body Total Carbohydrate and Fat Oxidation in Male Endurance and Ultra-Endurance Runners in Response to Prolonged Exercise, Consuming a Habitual Mixed Macronutrient Diet and Carbohydrate Feeding During Exercise. Front Physiol. 2022 Jan 4;12:773054. doi: 10.3389/fphys.2021.773054. eCollection 2021.

  PMID: 35058795 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Both the participants and investigators will be blinded to what supplement they are consuming on each visit. Each supplement will taste the same, and be placed into identical packaging, and be randomly labelled (e.g., A, B, C). This will be done to avoid potential bias.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This will be a double-blind randomised crossover design. There will be 1 group of participants who will complete all three conditions at random: Condition 1 - consume Voom Pocket Rocket. Condition 2 - consume SIS Isotonic Energy Gel. Condition 3 - consume Maurten Gel 160. Participants will consume each product 35 minutes before starting exercise. All participants will undergo the same exercise - 5 repeated sprint cycling (cycling against 0.075 kg/ kg body mass) intervals of 15 seconds interspersed with 3 minutes of active recovery. All participants will have the same measures taken - blood sampling for blood glucose, blood lactate, and electrolytes at the end of each sprint and period of active recovery, and monitoring of gas exchange throughout the exercise.

Study Record Dates

• First Submitted: January 6, 2025
• First Posted: January 10, 2025
• Study Start: January 6, 2025
• Primary Completion: February 5, 2025
• Study Completion: February 5, 2025
• Last Updated: March 6, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)