Postprandial Responses to Fish Intake

NCT06757608 | Active Not Recruiting

• 1 other identifier: 69418723.6.0000.0067
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Fish consumption has been increasing in recent decades due to consumer interest in the positive health effects of regular food intake, among other factors. Previous studies have described significant results on the acute consumption of fish products, favoring the reduction of triglycerides, total cholesterol, low-density lipoprotein, reduced insulin secretion, and increased plasma concentration of high-density lipoprotein during the postprandial period. Despite this scenario, studies investigating acute metabolic responses, such as postprandial physiological phenomena after consumption of the main fish species ingested by Brazilians, are still scarce. Thus, investigations of the acute effects of fish intake on postprandial metabolism may reveal new beneficial effects associated with this food group. The present proposal aims to compare the acute effects of the ingestion of two sources of fish and bovine protein on postprandial metabolism through the capillary blood sample collected within 5 hours after the ingestion of test meals, investigating hormones and inflammatory mediators and quantifying triglycerides, total cholesterol and non-esterified fatty acids and blood glucose, in addition to evaluating sensory aspects and satiety between different meals. It is expected to generate new data on postprandial physiology and investigate possible effects of fish ingestion that can contribute to public health management and healthy eating patterns.

Conditions

Post-prandial Glycaemic Response; Postprandial Lipids Metabolism; Postprandial Metabolism

Keywords

Cardiovascular diseases; Metabolism; Metabolomics; Fish; Dietary protein

Outcome Measures

Primary Outcomes (1)

• Plasma markers of intermediate metabolism and inflammation

  Capillary blood samples (approximately 500 µL) were collected after a 12-hour fasting and in different time points within a 5-hours interval after food intake to assess plasma metabolic and inflammatory markers (cytokines), aiming at identifying their response to the food intake.

  3 weeks

Secondary Outcomes (1)

• Urine metabolome

  3 weeks

Study Arms (3)

Tambaqui meat

ACTIVE COMPARATOR

Tambaqui (Colossoma macropomum) meat intake, 7g per BMI unit

Other: Assessment of postprandial metabolism after intake of different meat

Sardine meat

ACTIVE COMPARATOR

Sardine (Opisthonema oglinum) meat intake, 7g per BMI unit

Other: Assessment of postprandial metabolism after intake of different meat

Beef

ACTIVE COMPARATOR

Beef (Bos taurus) meat intake, 7g per BMI unit

Other: Assessment of postprandial metabolism after intake of different meat

Interventions

Assessment of postprandial metabolism after intake of different meat OTHER

30 healthy adults (15 male and 15 female) consumed sardines (Opisthonema oglinum, marine fish), tambaqui (Colossoma macropomum, freshwater culture), and beef (Bos taurus). The meal consisted only of meat, with 7g per BMI unit. The postprandial response was observed for 5 hours, after an overnight fast.

Beef; Sardine meat; Tambaqui meat

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults between 18 and 35 years and with a body mass index between 20 and 29 kg/m2.

You may not qualify if:

• Individuals with a vegetarian/vegan diet, a history of fish allergy, aversion to fish, used supplementation with n-3 polyunsaturated fatty acids or probiotics, who have a diagnosis of pregnancy, dyslipidemia, diabetes, inflammatory bowel disease, liver disease, who have undergone surgeries that alter the anatomy of the digestive tract (bariatric surgery or cholecystectomy, for example) and use of antimicrobial therapy in the 3 months before the study will not be allowed to participate.

Sponsors & Collaborators

• University of Sao Paulo: lead
• Fundação de Amparo à Pesquisa do Estado de São Paulo: collaborator
• Ministry of Education, Brazil: collaborator

Study Sites (1)

University of São Paulo

São Paulo, São Paulo, 05508-000, Brazil

Location

MeSH Terms

Conditions

Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor PhD

Model Details: Crossover Randomized Controlled Trial

Study Record Dates

• First Submitted: December 26, 2024
• First Posted: January 3, 2025
• Study Start: March 22, 2024
• Primary Completion: September 1, 2025
• Study Completion: December 1, 2025
• Last Updated: January 3, 2025

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)