NCT06752967

Brief Summary

The overall aim of the MEMORY study is to examine the concept of 'food memory' - how specific macronutrient compositions influence subsequent food preference and intake, and whether this differs across the BMI range from normal weight to obesity.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
45

participants targeted

Target at P25-P50 for not_applicable obesity

Timeline
2mo left

Started Dec 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress91%
Dec 2024Jun 2026

First Submitted

Initial submission to the registry

November 5, 2024

Completed
1 month until next milestone

Study Start

First participant enrolled

December 12, 2024

Completed
19 days until next milestone

First Posted

Study publicly available on registry

December 31, 2024

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 29, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 29, 2026

Last Updated

April 24, 2026

Status Verified

April 1, 2026

Enrollment Period

1.5 years

First QC Date

November 5, 2024

Last Update Submit

April 23, 2026

Conditions

ObesityNormal WeightOverweight

Keywords

ad libitum buffetFood preferencesMacronutrientAppetiteAppetite hormonesFGF21Glucagon

Outcome Measures

Primary Outcomes (1)

  • Difference in energy intake from sweet tasting carbohydrates.

    The difference in energy intake (E%) from sweet tasting carbohydrates during the ad libitum buffet in response to the high carbohydrate vs. high protein isocaloric liquid test meals.

    Measured after meal consumption at t=150 min

Secondary Outcomes (23)

  • Difference in self-reported energy intake

    Measured 24-hours after test visits

  • Difference in energy intake from fat

    Measured after meal consumption at t=150 min

  • Difference in energy intake from sweet tasting carbohydrates.

    Measured after meal consumption at t=150 min

  • Difference in energy intake from protein

    Measured after meal consumption at t=150 min

  • Food choice

    Measured during test visits (T=-60 min and T=120 min)

  • +18 more secondary outcomes

Study Arms (2)

Protein liquid test meal

EXPERIMENTAL

Liquid test meal high in protein.

Other: High protein liquid test meal

Carbohydrate liquid test meal

EXPERIMENTAL

Liquid test meal high in carbohydrates.

Other: High carbohydrate liquid test meal

Interventions

High protein liquid test mealOTHER

High protein liquid test meal consisting of whey protein, water and sugar-free coadial mix for flavour.

Protein liquid test meal
High carbohydrate liquid test mealOTHER

High carbohydrate liquid test meal consisting of sucrose, water and sugar-free coadial mix for flavour.

Carbohydrate liquid test meal

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age 18-45 years
  • For women: Regular menstruation
  • BMI-range 18.5-39.9 kg/m\^2

You may not qualify if:

  • Not able or willing to eat or drink the test meals because of e.g., allergy or intolerance
  • Daily smoking
  • For women: Pregnancy / planned pregnancy (within the study period) / lactating
  • Self-reported history of an eating disorder
  • HbA1c ≥48 mmol/mol
  • Treatment with antidepressants
  • Uncontrolled medical issues including but not limited to cardiovascular pulmonary, rheumatologic, hematologic, oncologic, infectious, gastrointestinal, or psychiatric disease; diabetes or other endocrine disease; immunosuppression
  • Current treatment with medication which significantly affect appetite or energy balance (e.g., GLP-1 receptor agonists)
  • Bariatric surgery
  • Unable to understand the informed consent and the study procedures
  • Concomitant participation in intervention studies
  • Participant's withdrawal of the informed consent
  • Other safety concerns - judged by the investigator

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Steno Diabetes Center Copenhagen

Herlev, Denmark, 2730, Denmark

RECRUITING

MeSH Terms

Conditions

ObesityOverweightFood Preferences

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsFeeding BehaviorBehavior

Study Officials

  • Jonas S Salling Quist, MSc, PhD

    Steno Diabetes Center Copenhagen

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jonas S. Quist, MSc, PhD

CONTACT

+45 26176064jonas.salling.quist@regionh.dk

Trine Spragge Ekblond, MSc

CONTACT

+45 28 12 55 44trine.spragge.ekblond@regionh.dk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Model Details: Randomized
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 5, 2024

First Posted

December 31, 2024

Study Start

December 12, 2024

Primary Completion (Estimated)

June 29, 2026

Study Completion (Estimated)

June 29, 2026

Last Updated

April 24, 2026

Record last verified: 2026-04

Locations

DK(1)