Biobank Cardiac Surgery

NCT06747806 | Recruiting

• 1 other identifier: IRB20-1974
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Treatment strategies for cardiac surgery patients have been evolving significantly for the last decade. While clinical outcomes have been improving, there are still significant areas unexplored in these patients. Cardiac surgery, or cardiovascular surgery, is surgery on the heart or great vessels performed by cardiac surgeons. It is often used to treat complications of ischemic heart disease (for example, with coronary artery bypass grafting); to correct congenital heart disease; or to treat valvular heart disease from various causes, including endocarditis, rheumatic heart disease, and atherosclerosis. Biobanking is a fundamental process required in the better understanding of human diseases together with their underlying mechanisms. Biobanking refers to the process by which samples of bodily fluid or tissue are collected for research use to improve the understanding of health and disease. For this study, the investigator's objective is to acquire elucidation in disease etiology, translation, and advancing public health by evaluating blood and tissue results of those with cardiac disease undergoing cardiac surgery.

Conditions

Cardiovascular Diseases

Outcome Measures

Primary Outcomes (3)

• Concentration of the elucidation in disease etiology from evaluating blood and tissue results

  To acquire elucidation in disease etiology health by evaluating blood and tissue results of those with cardiac disease undergoing cardiac surgery.

  From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

• Concentration of the elucidation in disease translation from evaluating blood and tissue results

  To acquire elucidation in disease translational health by evaluating blood and tissue results of those with cardiac disease undergoing cardiac surgery.

  From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

• Concentration of the elucidation in advancing public health by evaluating blood and tissue results

  To acquire elucidation in advancing public health by evaluating blood and tissue results of those with cardiac disease undergoing cardiac surgery.

  From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

Study Arms (1)

Patients who undergo cardiac surgery and procedures

Patients who undergo cardiac surgery and procedures will have tissue specimens that are removed during surgery and collected blood samples of 5 mL.

Procedure: Cardiac Surgery and Procedures

Interventions

Cardiac Surgery and Procedures PROCEDURE

To assess blood and tissue biomarkers of patients undergoing cardiac surgery

Patients who undergo cardiac surgery and procedures

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who undergo cardiac surgery at Advocate Children's Hospital (ACH)\& University of Chicago Medical Center (UCMC)

You may qualify if:

• All patients who undergo cardiac surgery at Advocate Children's Hospital (ACH)\& University of Chicago Medical Center (UCMC) by the ACH \& UC Cardiothoracic Surgery Research team who are pediatric neonates and up.
• Patients will only be English speaking.

You may not qualify if:

• Vulnerable Subjects/Subject Capacity to provide consent

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

The University of Chicago

Hyde Park, Illinois, 60637, United States

RECRUITING

MeSH Terms

Conditions

Cardiovascular Diseases

Interventions

Cardiac Surgical Procedures

Intervention Hierarchy (Ancestors)

Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Thoracic Surgical Procedures

Study Officials

• Valluvan Jeevanandam, MD

  University of Chicago

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Valluvan Jeevanandam, MD

CONTACT

7738345087; jeevan@bsd.uchicago.edu

Leila Yazdanbakhsh

CONTACT

7738345087; leila.yazdanbakhsh@bsd.uchicago.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 22, 2024
• First Posted: December 24, 2024
• Study Start: December 18, 2023
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: December 19, 2025

Record last verified: 2025-12

Locations

US (1)