NCT07224685

Brief Summary

The purpose of the study is to determine whether voice recordings acquired from patient-owned Android and Apple (iOS) smartphones can be used to monitor cardiovascular health. Voice signals will be processed to determine whether we can detect presence of cardiovascular disease and wellness, or if health risks exist.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000,000

participants targeted

Target at P75+ for all trials

Timeline
35mo left

Started Mar 2024

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress44%
Mar 2024Mar 2029

Study Start

First participant enrolled

March 5, 2024

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

November 3, 2025

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 5, 2025

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2029

Last Updated

November 5, 2025

Status Verified

October 1, 2025

Enrollment Period

5 years

First QC Date

November 3, 2025

Last Update Submit

November 3, 2025

Conditions

Cardiovascular Diseases

Outcome Measures

Primary Outcomes (1)

  • Total Patients Who Recorded a Voice Sample

    The total number of patients who recorded a voice sample will be defined as those completing a 30-second to 2-minute video, pronouncing vowel sounds or reading a short script as prompted by the Mayo Clinic App.

    Baseline

Study Arms (1)

Adult patients using the Mayo patient iPhone app

Other: Voice Recording

Interventions

Voice RecordingOTHER

Patients will record a 30-second to 2-minute video pronouncing vowel sounds or reading a short script. This will occur every 14 days for up to five years.

Adult patients using the Mayo patient iPhone app

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients who have the Mayo Clinic app and iOS 14 or Android smartphone (other types of smartphones will be added when functionality is added to the CDH app).

You may qualify if:

  • Adult patients using the Mayo patient iPhone app and iOS 14.0 or later (determined automatically via Mayo software) and Apple Watch v 4 or later (not SE), or if they have Android device for voice
  • Expressed interest in participation
  • Signed HIPPA authorization

You may not qualify if:

  • Age under 18

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

RECRUITING

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

  • Paul Friedman, M.D.

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Amanda Priebe

CONTACT

507-422-6932priebe.amanda@mayo.edu

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 3, 2025

First Posted

November 5, 2025

Study Start

March 5, 2024

Primary Completion (Estimated)

March 1, 2029

Study Completion (Estimated)

March 1, 2029

Last Updated

November 5, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will not share

Locations

US(1)