Evolution of the Relationship Between Central and Peripheral Arterial Wave Velocities as a Function of Age

NCT06742775 | Not Yet Recruiting

• 1 other identifier: 38RC24.0299
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Acquisition of synchronized cardiovascular signals from non-invasive measurements (ECG, photoplethysmography pulse sensors, inductance plethysmography) in healthy volunteers aged from 18 to 75, during spontaneous ventilation with apneas (20 seconds) for a total acquisition time of 30 minutes.

Conditions

Aging; Diagnostic Techniques, Cardiovascular

Keywords

photoplethysmography; electrocardiography; inductive plethysmography; Pulse Wave Velocity

Outcome Measures

Primary Outcomes (3)

• Electrocardiogram

  acquisition of ECG signals

  1 hour

• Photoplethysmography

  acquisition of peripheral and central photoplethysmographic signals with radial, brachial, carotid and femoral sensors

  1 hour

• inductive plethysmography

  acquisition of abdominal and thoracic section variations with an inductive plethysmographic vest

  1 hour

Secondary Outcomes (1)

• link between peripheral and central pulse wave velocity

  1 hour

Study Arms (3)

Under 30

Healthy volunteers younger than 30 years

Other: physiological signal acquisitions

Between 30 and 50

Healthy volunteers between 30 and 50 years

Other: physiological signal acquisitions

More than 50

Healthy volunteers older than 50 years

Other: physiological signal acquisitions

Interventions

physiological signal acquisitions OTHER

Subjects will be fitted with non-intrusive devices. In a semi-recumbent position, they will be asked to perform * 10 minutes of resting breathing * 10 cycles consisting of a 20-second apnea, to be performed at the end of inspiration, and 1 minute 40 of breathing (100 seconds). This single participation session will last a total of one hour for the volunteer (equipment, recording, de-equipping), including 30 minutes of acquisition.

Between 30 and 50; More than 50; Under 30

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

60 healthy volunteers: 3 groups of 20 volunteers per age category (under 30, between 30 and 50, over 50)

You may qualify if:

• Men and women between 18 and 75 years of age
• No acute cardiovascular pathologies less than 2 years old,
• No chronic cardiovascular pathologies.
• Stature compatible with the use of the plethysmography T-shirt.
• Person affiliated to a social security scheme or beneficiary of such a scheme
• Signed informed consent form

You may not qualify if:

• Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons under psychiatric care under articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, persons under legal protection or unable to express their consent).
• Personnel with a hierarchical link to the principal investigator
• Subjects excluded from another study,

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• University Grenoble Alps: collaborator

Study Sites (1)

Laboratoire TIMC

Grenoble, 38000, France

Location

Related Publications (14)

• Diaz A, Galli C, Tringler M, Ramirez A, Cabrera Fischer EI. Reference values of pulse wave velocity in healthy people from an urban and rural argentinean population. Int J Hypertens. 2014;2014:653239. doi: 10.1155/2014/653239. Epub 2014 Aug 24.

  PMID: 25215227 BACKGROUND

• Fontecave-Jallon J, Tanguy S. Inductive Plethysmography for aortic Pulse Wave Velocity. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2711-2714. doi: 10.1109/EMBC44109.2020.9175329.

  PMID: 33018566 BACKGROUND

• Fortier C, Agharazii M. Arterial Stiffness Gradient. Pulse (Basel). 2016 Apr;3(3-4):159-66. doi: 10.1159/000438852. Epub 2015 Sep 2.

  PMID: 27195235 BACKGROUND

• Fortier C, Sidibe A, Desjardins MP, Marquis K, De Serres SA, Mac-Way F, Agharazii M. Aortic-Brachial Pulse Wave Velocity Ratio: A Blood Pressure-Independent Index of Vascular Aging. Hypertension. 2017 Jan;69(1):96-101. doi: 10.1161/HYPERTENSIONAHA.116.08409. Epub 2016 Nov 7.

  PMID: 27821616 BACKGROUND

• Heffernan KS, Stoner L, London AS, Augustine JA, Lefferts WK. Estimated pulse wave velocity as a measure of vascular aging. PLoS One. 2023 Jan 26;18(1):e0280896. doi: 10.1371/journal.pone.0280896. eCollection 2023.

  PMID: 36701358 BACKGROUND

• Yu S, McEniery CM. Central Versus Peripheral Artery Stiffening and Cardiovascular Risk. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1028-1033. doi: 10.1161/ATVBAHA.120.313128. Epub 2020 Mar 19.

  PMID: 32188277 BACKGROUND

• Weber T, Wassertheurer S, Hametner B, Parragh S, Eber B. Noninvasive methods to assess pulse wave velocity: comparison with the invasive gold standard and relationship with organ damage. J Hypertens. 2015 May;33(5):1023-31. doi: 10.1097/HJH.0000000000000518.

  PMID: 25668350 BACKGROUND

• Wang J, Jing C, Hu X, Cui J, Tang Q, Tu L, Zhao S, Huang J, Guo D, Li Y, Xu J. Assessment of aortic to peripheral vascular stiffness and gradient by segmented upper limb PWV in healthy and hypertensive individuals. Sci Rep. 2023 Nov 13;13(1):19859. doi: 10.1038/s41598-023-46932-0.

  PMID: 37963909 BACKGROUND

• Townsend RR, Wilkinson IB, Schiffrin EL, Avolio AP, Chirinos JA, Cockcroft JR, Heffernan KS, Lakatta EG, McEniery CM, Mitchell GF, Najjar SS, Nichols WW, Urbina EM, Weber T; American Heart Association Council on Hypertension. Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association. Hypertension. 2015 Sep;66(3):698-722. doi: 10.1161/HYP.0000000000000033. Epub 2015 Jul 9. No abstract available.

  PMID: 26160955 BACKGROUND

• Sztrymf B, Jacobs F, Chemla D, Richard C, Millasseau SC. Validation of the new Complior sensor to record pressure signals non-invasively. J Clin Monit Comput. 2013 Dec;27(6):613-9. doi: 10.1007/s10877-013-9477-y. Epub 2013 May 17.

  PMID: 23681924 BACKGROUND

• Salvi P, Valbusa F, Kearney-Schwartz A, Labat C, Grillo A, Parati G, Benetos A. Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods. J Clin Med. 2022 Apr 15;11(8):2225. doi: 10.3390/jcm11082225.

  PMID: 35456316 BACKGROUND

• Salvi P, Lio G, Labat C, Ricci E, Pannier B, Benetos A. Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device. J Hypertens. 2004 Dec;22(12):2285-93. doi: 10.1097/00004872-200412000-00010.

  PMID: 15614022 BACKGROUND

• Obeid H, Khettab H, Marais L, Hallab M, Laurent S, Boutouyrie P. Evaluation of arterial stiffness by finger-toe pulse wave velocity: optimization of signal processing and clinical validation. J Hypertens. 2017 Aug;35(8):1618-1625. doi: 10.1097/HJH.0000000000001371.

  PMID: 28379892 BACKGROUND

• Karimpour P, May JM, Kyriacou PA. Photoplethysmography for the Assessment of Arterial Stiffness. Sensors (Basel). 2023 Dec 17;23(24):9882. doi: 10.3390/s23249882.

  PMID: 38139728 BACKGROUND

Study Officials

• Stéphane TANGUY

  University Grenoble Alpes

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Stéphane TANGUY

CONTACT

+33476637117; stephane.tanguy@univ-grenoble-alpes.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 11, 2024
• First Posted: December 19, 2024
• Study Start: February 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): February 1, 2027
• Last Updated: December 19, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)