NCT06727084

Brief Summary

Our study aims to investigate the predictive value of serum albumin and short-term mortality in patients with Acute Coronary Syndrome (ACS)

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2026

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 6, 2024

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 10, 2024

Completed
1.1 years until next milestone

Study Start

First participant enrolled

January 1, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2026

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2026

Completed
Last Updated

July 4, 2025

Status Verified

July 1, 2025

Enrollment Period

3 months

First QC Date

December 6, 2024

Last Update Submit

July 1, 2025

Conditions

Acute Coronary Syndrome

Keywords

Serum Albumin in Patients With Acute Coronary Syndrome

Outcome Measures

Primary Outcomes (1)

  • Value of Serum Albumin in Patients With Acute Coronary Syndrome

    low serum albumin is associated with increased adverse clinical outcomes and prognosis in cancer, heart failure, stroke, and stable coronary artery disease (CAD). Similarly, in patients with ACS, presence of hypoalbuminemia has been associated with increased severity of coronary lesions, no-reflow, increased in-hospital, and long-term mortality as well as development of heart failure

    12 week after the end of treatment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients aged 18 years or older who were admitted to the emergency department or coronary care unit with a diagnosis of acute coronary syndrome (ACS) will be eligible for inclusion.

You may not qualify if:

  • Patients with a history of chronic liver disease, nephrotic syndrome, or other conditions known to affect serum albumin levels.
  • Patients receiving albumin infusions or other treatments that could potentially interfere with serum albumin levels.
  • Patients with incomplete medical records or missing laboratory data.
  • Patients who declined to participate in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of medicine Sohag university

Sohag, Egypt

Location

Related Publications (4)

  • Chien SC, Chen CY, Leu HB, Su CH, Yin WH, Tseng WK, Wu YW, Lin TH, Chang KC, Wang JH, Wu CC, Yeh HI, Chen JW. Association of low serum albumin concentration and adverse cardiovascular events in stable coronary heart disease. Int J Cardiol. 2017 Aug 15;241:1-5. doi: 10.1016/j.ijcard.2017.04.003. Epub 2017 Apr 7.

    PMID: 28413113BACKGROUND

  • Polat N, Oylumlu M, Isik MA, Arslan B, Ozbek M, Demir M, Kaya H, Toprak N. Prognostic Significance of Serum Albumin in Patients With Acute Coronary Syndrome. Angiology. 2020 Nov;71(10):903-908. doi: 10.1177/0003319720941747. Epub 2020 Jul 17.

    PMID: 32677445BACKGROUND

  • D'Ascenzo F, Biondi-Zoccai G, Moretti C, Bollati M, Omede P, Sciuto F, Presutti DG, Modena MG, Gasparini M, Reed MJ, Sheiban I, Gaita F. TIMI, GRACE and alternative risk scores in Acute Coronary Syndromes: a meta-analysis of 40 derivation studies on 216,552 patients and of 42 validation studies on 31,625 patients. Contemp Clin Trials. 2012 May;33(3):507-14. doi: 10.1016/j.cct.2012.01.001. Epub 2012 Jan 11.

    PMID: 22265976BACKGROUND

  • Zegre-Hemsey JK, Asafu-Adjei J, Fernandez A, Brice J. Characteristics of Prehospital Electrocardiogram Use in North Carolina Using a Novel Linkage of Emergency Medical Services and Emergency Department Data. Prehosp Emerg Care. 2019 Nov-Dec;23(6):772-779. doi: 10.1080/10903127.2019.1597230. Epub 2019 Apr 17.

    PMID: 30885071BACKGROUND

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Study Officials

  • Osama A Arafa, Professor

    Faculty of Medicine Sohag University

    STUDY DIRECTOR

  • Hamdy S Mohamed, A .Professor

    Faculty of Medicine Sohag University

    STUDY DIRECTOR

  • Ahmed E Ebrahim, Lecturer

    Faculty of Medicine Sohag University

    STUDY DIRECTOR

Central Study Contacts

Magdy A Zaky, Resident

CONTACT

2011 29226770magdyadel@med.sohag.edu.eg

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Month
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Internal medicine Resident

Study Record Dates

First Submitted

December 6, 2024

First Posted

December 10, 2024

Study Start

January 1, 2026

Primary Completion

April 1, 2026

Study Completion

May 1, 2026

Last Updated

July 4, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)