The Impact of a Caffeinated Sports Drink on Performance

NCT06721793 | Completed

• 2 other identifiers: FP00041543AWD00039989
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Caffeine is known to enhance physical and mental performance, but few beverages combine caffeine with electrolytes and carbohydrates to enhance exercise performance. This study evaluates a caffeinated electrolyte-glucose drink's effect on endurance, strength, and cognition. Using a repeated-measures, cross-over design, 20 trained cyclists will complete one familiarization and four randomized 3-hour experimental trials (Liquid I.V.™ Energy Multiplier, Hydration Multiplier, Sugar-Free Hydration Multiplier, and water). Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments. Cycling performance, capillary blood, urine, and expiratory gases will be collected.

Conditions

Dehydration; Dehydration Related to Exercise

Keywords

caffeine; sports drinks; hydration

Outcome Measures

Primary Outcomes (6)

• 5 kilometer cycling time trial

  Time in minutes of completion the 5 kilometer cycling time trial at the 3rd exercise bout.

  During the 3rd time trial which is the last time trial.

• 5 kilometer Time trial performance

  Time to completion the 2nd cycling time trial

  2nd time trial

• Isokinetic stregth

  Peak torque at 60º/sec at dominant knee during extension

  right after the cycling tests

• Congitive performance 1

  Attention Network Test score

  after the completion of strength test

• Cognitive performance 2

  Working Memory Test score

  after the end of the strength assessment

• Congitive test 3

  Stroop Task score

  right after the strength test

Secondary Outcomes (1)

• Blood glucose

  at the end of the 3rd cycling time trial.

Study Arms (4)

Water

PLACEBO COMPARATOR

Water masked with non-caloric and no-sodium

Dietary Supplement: Water (Placebo)

Carbohydrate electrolyte solution

EXPERIMENTAL

2% carbohydrate solution with 1,020 mg/L of Sodium

Dietary Supplement: carbohydrate electrolyte drink

no-sugar electrolyte solution

EXPERIMENTAL

1% carbohydrate solution with 1,060 mg/L of Sodium

Dietary Supplement: no-sugar electrolyte drink

Caffeinated carbohydrate electrolyte solution

EXPERIMENTAL

1% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L Caffeine

Dietary Supplement: Caffeinated Carbohydrate and electrolyte drink

Interventions

carbohydrate electrolyte drink DIETARY_SUPPLEMENT

2% carbohydrate solution with 1,020 mg/L of Sodium

Carbohydrate electrolyte solution

no-sugar electrolyte drink DIETARY_SUPPLEMENT

1% carbohydrate solution with 1,060 mg/L of Sodium

no-sugar electrolyte solution

Water (Placebo) DIETARY_SUPPLEMENT

flavored water with non-caloric, non-sodium-containing sweetner

Water

Caffeinated Carbohydrate and electrolyte drink DIETARY_SUPPLEMENT

2% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L caffeine

Caffeinated carbohydrate electrolyte solution

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-55
• Healthy and injury-free (muscle, skeletal) for greater than 2 months
• Active cyclists who train at least 3 times per week
• Body mass index (BMI) range of 18.5-30 kg/m2

You may not qualify if:

• History of caffeine sensitivity
• Cancer Diagnosis during the last 5 years
• Pregnancy
• History of renal disease, hypertension
• History of a heat stroke
• Use of testosterone therapy
• Adults who are unable to consent (impaired decision-making capacity)

Sponsors & Collaborators

• Arizona State University: lead

Study Sites (1)

Arizona State University - Hydration Science Lab

Phoenix, Arizona, 85004, United States

Location

MeSH Terms

Conditions

Dehydration

Interventions

Water

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Officials

• Stavros Kavouras, PhD

  Arizona State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The type of drink ingested by the subjects will be labeled with a letter in a generic water bottle. During the trial with water a non-caloric, non-sodium-containing sweetener will be used.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Counter balanced cross-over design trial with 4 arms differing only on the type of drink consumed during exercise. Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments.

Study Record Dates

• First Submitted: October 3, 2024
• First Posted: December 6, 2024
• Study Start: December 12, 2025
• Primary Completion: December 16, 2025
• Study Completion: December 16, 2025
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)