Rehydration Efficiency During Ad-libitum Fluid Intake

NCT06414291 | Completed

• 1 other identifier: FP00039672
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin. The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.

Conditions

Dehydration

Outcome Measures

Primary Outcomes (10)

• Total fluid intake

  Total amount of fluid ingested

  4 hours of rehydration

• Net fluid balance

  amount of water retained during the rehydration period

  at 4 hours of the rehydration period

• Net fluid balance

  amount of water retained during the rehydration period

  at 3 hours of the rehydration period

• Rate of absorption

  The rate of Deuterium appearance in the blood during 30 minutes of rehydration

  during the first 30 minutes of rehydration

• Rate of absorption

  The rate of Deuterium appearance in the blood during 60 minutes of rehydration

  during the first 60 minutes of rehydration

• Rate of absorption

  The rate of Deuterium appearance in the blood during 120 minutes of rehydration

  during the first 120 minutes of rehydration

• Rate of absorption

  The rate of Deuterium appearance in the blood during 180 minutes of rehydration

  during the first 180 minutes of rehydration

• Rate of absorption

  The rate of Deuterium appearance in the blood during 240 minutes of rehydration

  during the first 240 minutes of rehydration

• Cumulative urine output

  Total amount of urine output during rehydration

  during the first 3 hours of rehydration

• Cumulative urine output

  Total amount of urine output during rehydration

  during the first 4 hours of rehydration

Secondary Outcomes (7)

• Plasma copeptin

  at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

• Plasma volume

  at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

• Free water Clearance

  at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

• Free Osmotic Clearance

  at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

• Thirst

  at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

Study Arms (3)

Water

PLACEBO COMPARATOR

Rehydration with low mineral content bottle water

Other: Plain Water

Carbohydrate Electrolyte solution

EXPERIMENTAL

Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV

Other: Liquid IV Hydration Multiplier

Low Sugar electrolyte solution

EXPERIMENTAL

10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV

Other: Liquid IV Sugar Free

Interventions

Plain Water OTHER

Plain water without calories, sweetener, or electolytes

Water

Liquid IV Hydration Multiplier OTHER

Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV

Carbohydrate Electrolyte solution

Liquid IV Sugar Free OTHER

10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV

Low Sugar electrolyte solution

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-60 years
• Training at least 2 times per week
• stable weight for the last 2 months (fluctuation less than 5 pounds)

You may not qualify if:

• Night shifting work
• Thyroid medication
• Bariatric surgery
• Cardiovascular disease
• Renal disease
• Hepatic disease
• Participating in another study at the same time
• Bodyweight over 110 pounds

Sponsors & Collaborators

• Arizona State University: lead

Study Sites (1)

Interdisciplinary Science and Technology Building 8

Phoenix, Arizona, 85004, United States

Location

MeSH Terms

Conditions

Dehydration

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: non labeled bottles
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor & Assistant Dean

Study Record Dates

• First Submitted: May 7, 2024
• First Posted: May 16, 2024
• Study Start: May 21, 2024
• Primary Completion: December 2, 2024
• Study Completion: December 3, 2024
• Last Updated: August 28, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)