Dehydration Cognition

NCT05916183 | Completed

• 1 other identifier: STUDY00007342
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators want to understand the impact of the body losing and gaining water on brain function. Participants will restrict fluids consumed and exercise to lose 5% of body mass. Participants will then be provided fluid equal to the volume lost to consume over 2 hours (recovery). A series of brain function tests will be performed at baseline, following weight loss, and following recovery.

Conditions

Dehydration

Outcome Measures

Primary Outcomes (2)

• Multitasking test

  Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome

  Upon completion of 5% body mass loss protocol, approximately 2 hours into the trial

• Multitasking test

  Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome

  2 hours following the dehydration cognitive function test, approximately 4.5 hours into the trial

Study Arms (1)

Dehydration and Rehydration Arm

EXPERIMENTAL

Participants will complete exercise until 5% body mass loss, followed by ad libitum rehydration throughout 2 hours of recovery.

Behavioral: Fluid loss and consumption

Interventions

Fluid loss and consumption BEHAVIORAL

Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period

Dehydration and Rehydration Arm

Eligibility Criteria

• Age: 18 Years - 26 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Recreationally active
• years old

You may not qualify if:

• History of cardiovascular, metabolic, respiratory, neural, or renal disease
• Hypertensive (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg) or tachycardic (resting heart rate ≥ 100 bpm) during the screening visit
• Taking medication or supplements with a known side effect of affecting physiological responses to exercise (e.g., aspirin, acetaminophen, beta blockers, statins, stimulants, depressants, SSRIs)
• Tobacco or nicotine use in the past six months
• Current or past musculoskeletal injury impacting physical activity
• Study physician discretion based on any other medical condition or medication

Sponsors & Collaborators

• State University of New York at Buffalo: lead

Study Sites (1)

University at Buffalo

Buffalo, New York, 14214, United States

Location

MeSH Terms

Conditions

Dehydration

Interventions

Economics

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Health Care Economics and Organizations

Study Officials

• Riana R Pryor, PhD

  University at Buffalo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 5, 2023
• First Posted: June 23, 2023
• Study Start: July 5, 2023
• Primary Completion: December 22, 2023
• Study Completion: December 22, 2023
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data can be shared for as long as the data is retained, at least 7 years.
• Access Criteria: Data will be shared upon reasonable written request.

Locations

US (1)